日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small Gold Nanoparticles Alleviate Huntington's Disease via Modulating p38α Mitogen-Activated Protein Kinase and Pyruvate Dehydrogenase Kinase 1

小金纳米颗粒通过调节p38α丝裂原活化蛋白激酶和丙酮酸脱氢酶激酶1缓解亨廷顿病

Lee, Leo Kit Cheung; Leong, Lok I; Shyngys, Moldir; Bai, Qianqian; Lui, Ying Lam; Cui, Can; Liu, Shaorui; Xiao, Yu; Chan, Cecilia Ka Wing; Cheung, Wing-Hoi; Kwan, Kin Ming; Chan, Ho Yin Edwin; Choi, Chung Hang Jonathan

Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy.

在果蝇强直性肌营养不良模型中,突触前和突触后 FasII 的上调协同作用,导致神经病理学和行为表型。

Koon Alex Chun, Yeung Ka Yee Winnie, Wu Yitao, Leong Lok I, Cheung John Tsun Po, Chen Zhefan Stephen, Peng Shaohong Isaac, Armstrong Noah S, Frank C Andrew, Magneron Paul, Gomes-Pereira Mário, Fung Joyce Man See, Bargiela Ariadna, Moreno Nerea, Poyatos-Garcia Javier, Vilchez Juan, Huguet-Lachon Aline, Brewer Cassandra Kussius, Zinter Max, Beck Erin S, Artero Rubén, Gourdon Genevieve, Budnik Vivian, Thomson Travis, McCabe Brian D, Chan Ho Yin Edwin

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5.

突变亨廷顿蛋白通过解除对非经典聚腺苷酸聚合酶 PAPD5 的抑制来诱导神经元凋亡

Chen Zhefan Stephen, Peng Shaohong Isaac, Leong Lok I, Gall-Duncan Terence, Wong Nathan Siu Jun, Li Tsz Ho, Lin Xiao, Wei Yuming, Koon Alex Chun, Huang Junzhe, Sun Jacquelyne Ka-Li, Turner Clinton, Tippett Lynette, Curtis Maurice A, Faull Richard L M, Kwan Kin Ming, Chow Hei-Man, Ko Ho, Chan Ting-Fung, Talbot Kevin, Pearson Christopher E, Chan Ho Yin Edwin

Gene delivery of SUMO1-derived peptide rescues neuronal degeneration and motor deficits in a mouse model of Parkinson's disease.

基因递送SUMO1衍生肽可挽救帕金森病小鼠模型中的神经元退化和运动缺陷

Liang Zhaohui, Murugappan Suresh Kanna, Li Yuxuan, Lai Man Nga, Qi Yajing, Wang Yi, Chan Ho Yin Edwin, Lee Marianne M, Chan Michael K

Genotypic, functional, and phenotypic characterization in CTNNB1 neurodevelopmental syndrome.

CTNNB1神经发育综合征的基因型、功能和表型特征

Žakelj Nina, Gosar David, Miroševič Špela, Sanders Stephan J, Ljungdahl Alicia, Kohani Sayeh, Huang Shouhe, Leong Lok I, An Ying, Teo Miou-Jing, Moultrie Fiona, Jerala Roman, Lainšček Duško, Forstnerič Vida, Sušjan Petra, Lisowski Leszek, Perez-Iturralde Andrea, Mrak Jasna Oražem, Chan Ho Yin Edwin, Osredkar Damjan

The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing.

细胞衔接蛋白 GULP1 与 ATG14 相互作用,增强自噬和 APP 加工

Chau Dennis Dik-Long, Yu Zhicheng, Chan Wai Wa Ray, Yuqi Zhai, Chang Raymond Chuen Chung, Ngo Jacky Chi Ki, Chan Ho Yin Edwin, Lau Kwok-Fai

Development of Fluorescent Turn-On Probes for CAG-RNA Repeats

CAG-RNA重复序列荧光开启探针的开发

Lau, Matthew Ho Yan; Wong, Chun-Ho; Chan, Ho Yin Edwin; Au-Yeung, Ho Yu

A heterozygous mutation in the CCDC88C gene likely causes early-onset pure hereditary spastic paraplegia: a case report

CCDC88C基因杂合突变可能导致早发性纯遗传性痉挛性截瘫:病例报告

Yahia, Ashraf; Chen, Zhefan Stephen; Ahmed, Ammar E; Emad, Sara; Adil, Rawaa; Abubaker, Rayan; Taha, Shaimaa Omer M A; Salih, Mustafa A; Elsayed, Liena; Chan, Ho Yin Edwin; Stevanin, Giovanni

Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis

泛癌症研究揭示了平面细胞极性基因 Fuz 在致癌作用中的机制见解

Zhefan Stephen Chen, Xiao Lin, Ting-Fung Chan, Ho Yin Edwin Chan

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

一种肽类抑制剂,用于中和多聚谷氨酰胺疾病中扩增的 CAG RNA 诱导的核仁应激。

Zhang, Qian; Chen, Zhefan Stephen; An, Ying; Liu, Haizhen; Hou, Yonghui; Li, Wen; Lau, Kwok-Fai; Koon, Alex Chun; Ngo, Jacky Chi Ki; Chan, Ho Yin Edwin