日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo

引导RNA 3'末端区域中磷酸二酯骨架的存在(而非核碱基的存在)是RISC在体外和体内装载和靶标切割所必需的。

O'Reilly, Daniel; Furgal, Raymond C; Ross, Vella M; Luu, Eric; Gross, Katherine Y; Hariharan, Vignesh; Summers, Ashley; Cooper, David; Allen, Sarah; Dahlke, Christopher; Rachid, Mohamad Omar; Chan, Io Long; Fakih, Hassan H; Alterman, Julia F; Echeverria, Dimas; Watts, Jonathan K; Khvorova, Anastasia

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts

气管内注射LNA gapmer反义寡核苷酸可诱导小鼠肺成纤维细胞中强烈的基因沉默。

Shin, Minwook; Chan, Io Long; Cao, Yuming; Gruntman, Alisha M; Lee, Jonathan; Sousa, Jacquelyn; Rodríguez, Tomás C; Echeverria, Dimas; Devi, Gitali; Debacker, Alexandre J; Moazami, Michael P; Krishnamurthy, Pranathi Meda; Rembetsy-Brown, Julia M; Kelly, Karen; Yukselen, Onur; Donnard, Elisa; Parsons, Teagan J; Khvorova, Anastasia; Sontheimer, Erik J; Maehr, René; Garber, Manuel; Watts, Jonathan K

Effects of Larval Density on Gene Regulation in Caenorhabditis elegans During Routine L1 Synchronization.

线虫幼虫密度对秀丽隐杆线虫常规 L1 同步化过程中基因调控的影响

Chan Io Long, Rando Oliver J, Conine Colin C