日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR-Cas9-mediated homology-directed repair rescues the induced bone marrow failure in Fancc (-/-) mice

CRISPR-Cas9介导的同源定向修复可挽救Fancc(-/-)小鼠的诱导性骨髓衰竭。

Harikrishnan, Hemavathy; Lamsal, Mahesh; Chan, Ka-Kui; Zhang, Junping; Tian, Jiahe; Fosu, Kwadwo; Nguyen, Hong Phuong; Clapp, D Wade; Sierra Potchanant, Elizabeth A; Kapur, Reuben; Xiao, Weidong; Tran, Ngoc Tung

A haploinsufficiency restoration strategy corrects neurobehavioral deficits in Nf1+/- mice.

单倍体功能不全恢复策略可纠正 Nf1+/- 小鼠的神经行为缺陷

Park Su Jung, Lukkes Jodi L, Chan Ka-Kui, Drozd Hayley P, Burgin Callie B, Qian Shaomin, Sullivan Morgan McKenzie, Guevara Cesar Gabriel, Cunningham Nolen, Arenas Stephanie, Collins Makenna A, Zucker Jacob, Won JinHee, Smith Abbi, Jiang Li, Mitchell Dana K, Rhodes Steven D, Angus Steven P, Clapp D Wade

PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia.

PLK1 抑制可导致范可尼贫血通路缺陷型急性髓系白血病发生合成致死

Sheth Aditya S, Chan Ka-Kui, Liu Sheng, Wan Jun, Angus Steve P, Rhodes Steven D, Mitchell Dana K, Davis Christopher, Ridinger Maya, Croucher Peter J, Zeidan Amer M, Wijeratne Aruna, Qian Shaomin, Tran Ngoc Tung, Sierra Potchanant Elizabeth A

SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells.

SIK2 激酶合成致死性是由 FANCA 缺陷细胞中的纺锤体组装缺陷驱动的

Chan Ka-Kui, Abdul-Sater Zahi, Sheth Aditya, Mitchell Dana K, Sharma Richa, Edwards Donna M, He Ying, Nalepa Grzegorz, Rhodes Steven D, Clapp D Wade, Sierra Potchanant Elizabeth A

Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways

Ran是癌细胞的潜在治疗靶点,其分子变化与PI3K/Akt/mTORC1和Ras/MEK/ERK通路激活有关。

Yuen, Hiu-Fung; Chan, Ka-Kui; Grills, Claire; Murray, James T; Platt-Higgins, Angela; Eldin, Osama Sharaf; O'Byrne, Ken; Janne, Pasi; Fennell, Dean A; Johnston, Patrick G; Rudland, Philip S; El-Tanani, Mohamed

Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression

骨形态发生蛋白6、noggin和SOST的组合应用可显著预测癌症进展。

Yuen, Hiu-Fung; McCrudden, Cian M; Grills, Claire; Zhang, Shu-Dong; Huang, Yu-Han; Chan, Ka-Kui; Chan, Yuen-Piu; Wong, Michelle Lok-Yee; Law, Simon; Srivastava, Gopesh; Fennell, Dean A; Dickson, Glenn; El-Tanani, Mohamed; Chan, Kwok-Wah