日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques

Smac 模拟物与 eCD4-Ig 联合使用可逆转恒河猴的潜伏感染,且不减少 SHIV 病毒库。

Pache, Lars; Bui, John K; Klouser, Lindsay M; Fennessey, Christine M; Noyola, Alexander C; Einhaus, Teresa; Zhu, Haiying; Stensland, Laurence; Leguizamo, Isai; Koroma, Abubakarr A; Teriete, Peter; Chang, W L William; Hyrien, Ollivier; Duggan, Natasha N; Heimann, Dominik; Pérez-Osorio, Ailyn C; Bar, Katharine J; Cosford, Nicholas Dp; Keele, Brandon F; Hartigan-O'Connor, Dennis J; Farzan, Michael; Gardner, Matthew R; Jerome, Keith R; Chanda, Sumit K; Kiem, Hans-Peter; Peterson, Christopher W

Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.

全球 siRNA 筛选确定了对 SARS-CoV-2 复制和感染后期至关重要的人类宿主因子

Yin Xin, Pu Yuan, Yuan Shuofeng, Pache Lars, Churas Christopher, Weston Stuart, Riva Laura, Simons Lacy M, Cisneros William J, Clausen Thomas, Biddle Grace, Doss-Gollin Simon, Deming Meagan, De Jesus Paul D, Kim Ha Na, Fuentes Daniel, Whitelock John M, Esko Jeffrey D, Lord Megan S, Mena Ignacio, García-Sastre Adolfo, Hultquist Judd F, Frieman Matthew B, Ideker Trey, Pratt Dexter, Martin-Sancho Laura, Chanda Sumit K

Integrative multi-omics analysis in vivo identifies influenza virus host factors.

体内整合多组学分析鉴定流感病毒宿主因子。

Shriver Leah P, Polacco Benjamin J, Eckhardt Manon, Chang Max W, Martínez-Romero Carles, Adkins-Travis Kayla, Cahalane Celina, Haas Kelsey, Stein David A, Fourati Slim, Martin-Sancho Laura, Metreveli Giorgi, Johnson Jeffrey R, Muñoz-Moreno Raquel, Newton Billy W, Kaake Robyn M, Zhou Yuan, Jimenez-Morales David, VonDollen John, Verschueren Erik, Swaney Danielle L, Nguyen Thong T, Stevenson Erica J, Stancliffe Ethan, Patti Gary J, Albrecht Randy, Moulton Hong M, Pache Lars, Sekaly Rafick P, Benner Christopher, Hultquist Judd F, Chanda Sumit K, Garcia-Sastre Adolfo, Krogan Nevan J

Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice

PQBP1与HIV-1衣壳晶格结合的分子决定因素

Piacentini, Juliana; Allen, Dale S; Ganser-Pornillos, Barbie K; Chanda, Sumit K; Yoh, Sunnie M; Pornillos, Owen

Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2

SARS-CoV-2 感染滋养层细胞后干扰素通路被激活

Kallol, Sampada; Martin-Sancho, Laura; Morey, Robert; Aisagbonhi, Omonigho; Pizzo, Donald; Meads, Morgan; Chanda, Sumit K; Soncin, Francesca

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

SARS-CoV-2 Orf6 劫持 Nup98 以阻断 STAT 核输入并拮抗干扰素信号传导

Miorin, Lisa; Kehrer, Thomas; Sanchez-Aparicio, Maria Teresa; Zhang, Ke; Cohen, Phillip; Patel, Roosheel S; Cupic, Anastasija; Makio, Tadashi; Mei, Menghan; Moreno, Elena; Danziger, Oded; White, Kris M; Rathnasinghe, Raveen; Uccellini, Melissa; Gao, Shengyan; Aydillo, Teresa; Mena, Ignacio; Yin, Xin; Martin-Sancho, Laura; Krogan, Nevan J; Chanda, Sumit K; Schotsaert, Michael; Wozniak, Richard W; Ren, Yi; Rosenberg, Brad R; Fontoura, Beatriz M A; García-Sastre, Adolfo

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

NLRX1通过隔离STING来负向调节干扰素反应,从而促进HIV-1和DNA病毒的复制。

Guo, Haitao; König, Renate; Deng, Meng; Riess, Maximilian; Mo, Jinyao; Zhang, Lu; Petrucelli, Alex; Yoh, Sunnie M; Barefoot, Brice; Samo, Melissa; Sempowski, Gregory D; Zhang, Aiping; Colberg-Poley, Anamaris M; Feng, Hui; Lemon, Stanley M; Liu, Yong; Zhang, Yanping; Wen, Haitao; Zhang, Zhigang; Damania, Blossom; Tsao, Li-Chung; Wang, Qi; Su, Lishan; Duncan, Joseph A; Chanda, Sumit K; Ting, Jenny P-Y

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

BIRC2/cIAP1是HIV-1转录的负调控因子,可作为Smac模拟物的靶点,以促进病毒潜伏期的逆转。

Pache, Lars; Dutra, Miriam S; Spivak, Adam M; Marlett, John M; Murry, Jeffrey P; Hwang, Young; Maestre, Ana M; Manganaro, Lara; Vamos, Mitchell; Teriete, Peter; Martins, Laura J; König, Renate; Simon, Viviana; Bosque, Alberto; Fernandez-Sesma, Ana; Cosford, Nicholas D P; Bushman, Frederic D; Young, John A T; Planelles, Vicente; Chanda, Sumit K

MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells

MxB并非α干扰素处理细胞中观察到的HIV-1感染阻断的原因。

Opp, Silvana; Vieira, Daniel A S A; Schulte, Bianca; Chanda, Sumit K; Diaz-Griffero, Felipe

RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.

RIOK3 是一种衔接蛋白,是 IRF3 介导的抗病毒 I 型干扰素产生所必需的

Feng Jun, De Jesus Paul D, Su Victoria, Han Stephanie, Gong Danyang, Wu Nicholas C, Tian Yuan, Li Xudong, Wu Ting-Ting, Chanda Sumit K, Sun Ren