日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation.

E6AP 与 HPV16-E6 和 p53 复合物的结构揭示了一种对 E3 连接酶激活至关重要的新型有序结构域

Kenny Sebastian, Iyer Shalini, Gabel Clinton A, Tegenfeldt Natalia, DeMarco Andrew G, Hall Mark C, Chang Leifu, Davisson V Jo, Pol Scott Vande, Das Chittaranjan

Structural basis of RNA-guided transcription by a dCas12f-σ(E)-RNAP complex

dCas12f-σ(E)-RNAP复合物介导的RNA转录的结构基础

Xiao, Renjian; Hoffmann, Florian T; Xie, Dan; Wiegand, Tanner; Palmieri, Adriana I; Sternberg, Samuel H; Chang, Leifu

Exapted CRISPR-Cas12f homologs drive RNA-guided transcription.

适应性 CRISPR-Cas12f 同源物驱动 RNA 引导的转录

Hoffmann Florian T, Wiegand Tanner, Palmieri Adriana I, Glass-Klaiber Juniper, Xiao Renjian, Tang Stephen, Le Hoang, Meers Chance, Lampe George D, Chang Leifu, Sternberg Samuel H

Cryo-EM structures of apo-APC/C and APC/C(CDH1:EMI1) complexes provide insights into APC/C regulation

冷冻电镜解析的apo-APC/C和APC/C(CDH1:EMI1)复合物结构为APC/C的调控提供了新的见解。

Höfler, Anna; Yu, Jun; Yang, Jing; Zhang, Ziguo; Chang, Leifu; McLaughlin, Stephen H; Grime, Geoffrey W; Garman, Elspeth F; Boland, Andreas; Barford, David

Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor

AcrIF24作为抗CRISPR蛋白和转录抑制因子的结构基础

Mukherjee, Indranil Arun; Gabel, Clinton; Noinaj, Nicholas; Bondy-Denomy, Joseph; Chang, Leifu

Structural basis for inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4, AcrIF7 and AcrIF14

AcrIF4、AcrIF7 和 AcrIF14 抑制 IF 型 CRISPR-Cas 监视复合物的结构基础

Gabel, Clinton; Li, Zhuang; Zhang, Heng; Chang, Leifu

Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease

二聚化依赖性 CRISPR-Cas12f 核酸酶识别和切割底物的结构基础

Xiao, Renjian; Li, Zhuang; Wang, Shukun; Han, Ruijie; Chang, Leifu

Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease

Cas12i RNA引导的核酸内切酶识别和切割靶标的机制

Zhang, Heng; Li, Zhuang; Xiao, Renjian; Chang, Leifu

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain

APC/C亚基Apc4和Apc5 N端结构域的原子分辨率结构

Cronin, Nora B; Yang, Jing; Zhang, Ziguo; Kulkarni, Kiran; Chang, Leifu; Yamano, Hiroyuki; Barford, David