Chimeric PD‑1 receptor redirects primary T cells against childhood solid tumors but not to PD‑1 ligand‑positive CD80‑coexpressing cells
嵌合型PD-1受体可将原代T细胞重定向至针对儿童实体瘤的靶点,但不会重定向至PD-1配体阳性且共表达CD80的细胞。
期刊:Molecular Medicine Reports
影响因子:3.5
doi:10.3892/mmr.2025.13608
Shin, Chansu; Imamura, Masaru; Kasahara, Yasushi; Suzuki, Yuko; Baba, Minori; Kubo, Nobuhiro; Hosokai, Ryosuke; Iwabuchi, Haruko; Murayama, Yudai; Kawashima, Hiroyuki; Ogose, Akira; Mihara, Keichiro; Saitoh, Akihiko; Imai, Chihaya
T细胞
信号转导
CD8
CD80
T细胞
细胞生物学
PD-1
免疫/内分泌