Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells
连续缺氧通过下调 NKX2-1 降低 NOTCH3、HEY1、CC10 和 FOXJ1 的表达,而间歇性缺氧-复氧通过上调 HIF1A 增加人支气管上皮细胞中 BMP4、NOTCH1、MKI67、OCT4 和 MUC5AC 的表达
期刊:Frontiers in Cell and Developmental Biology
影响因子:4.6
doi:10.3389/fcell.2020.572276
Yung-Yu Yang, Chao-Ju Lin, Cheng-Chin Wang, Chieh-Min Chen, Wen-Jen Kao, Yi-Hui Chen
信号转导
上皮细胞
FCM
IF
WB
Notch
Human
HIF1A