日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

PP2A 激活药物选择性清除 TKI 耐药慢性粒细胞白血病干细胞

Paolo Neviani, Jason G Harb, Joshua J Oaks, Ramasamy Santhanam, Christopher J Walker, Justin J Ellis, Gregory Ferenchak, Adrienne M Dorrance, Carolyn A Paisie, Anna M Eiring, Yihui Ma, Hsiaoyin C Mao, Bin Zhang, Mark Wunderlich, Philippa C May, Chaode Sun, Sahar A Saddoughi, Jacek Bielawski, William

(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity

(S)-FTY720-乙烯基膦酸酯是免疫抑制剂 FTY720 的类似物,是鞘氨醇 1-磷酸 GPCR 信号的泛拮抗剂,可抑制自分泌运动因子活性

William J Valentine, Gyöngyi N Kiss, Jianxiong Liu, Shuyu E, Mari Gotoh, Kimiko Murakami-Murofushi, Truc Chi Pham, Daniel L Baker, Abby L Parrill, Xuequan Lu, Chaode Sun, Robert Bittman, Nigel J Pyne, Gabor Tigyi