日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Uncovering the structural impact of KatG Ser315 mutations in Mycobacterium tuberculosis via cryo-EM

利用冷冻电镜揭示结核分枝杆菌中KatG Ser315突变的结构影响

Allport, Thomas; Chaplin, Amanda K

Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis

结核分枝杆菌Ku蛋白的寡聚化促进DNA突触形成

Zahid, Sayma; Baconnais, Sonia; Smith, Henrietta; Atwal, Saseela; Bates, Lucy; Read, Harriet; Chadda, Ankita; Morati, Florian; Bedwell, Tom; Stender, Emil G P; Walter, Joanne; Hardwick, Steven W; Westerlund, Fredrik; Galburt, Eric; Le Cam, Eric; Pyne, Alice; Mukamolova, Galina V; Chaplin, Amanda K

Cryo-EM structures of NHEJ assemblies with nucleosomes

核小体参与的NHEJ组装体的冷冻电镜结构

Hall, Chloe; Frit, Philippe; Kefala-Stavridi, Antonia; Pelletier, Amandine; Hardwick, Steven W; Amin, Himani; Bilyard, Matthew K; Maia De Oliviera, Taiana; Tariq, Ammarah; Zahid, Sayma; Chirgadze, Dimitri Y; Balasubramanian, Shankar; Meek, Katheryn; Ropars, Virginie; Charbonnier, Jean-Baptiste; Modesti, Mauro; Calsou, Patrick; Britton, Sébastien; Blundell, Tom L; Schalch, Thomas; Chaplin, Amanda K

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ.

对Ku70/80和Pol X家族聚合酶在NHEJ中的相互作用的结构和功能见解

Frit Philippe, Amin Himani, Zahid Sayma, Barboule Nadia, Hall Chloe, Matharu Gurdip, Hardwick Steven W, Chauvat Jeanne, Britton Sébastien, Chirgadze Dima Y, Ropars Virginie, Charbonnier Jean-Baptiste, Calsou Patrick, Chaplin Amanda K

The oligomeric states of dye-decolorizing peroxidases from Streptomyces lividans and their implications for mechanism of substrate oxidation

链霉菌(Streptomyces lividans)染料脱色过氧化物酶的寡聚状态及其对底物氧化机制的影响

Lučić, Marina; Allport, Thomas; Clarke, Thomas A; Williams, Lewis J; Wilson, Michael T; Chaplin, Amanda K; Worrall, Jonathan A R

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining.

两种不同的长程突触复合物促进DNA断裂通过非同源末端连接修复之前末端加工的不同方面

Buehl Christopher J, Goff Noah J, Hardwick Steven W, Gellert Martin, Blundell Tom L, Yang Wei, Chaplin Amanda K, Meek Katheryn

SAP domain forms a flexible part of DNA aperture in Ku70/80

在 Ku70/80 中,SAP 结构域构成 DNA 孔道的柔性部分。

Hnízda, Aleš; Tesina, Petr; Nguyen, Thanh-Binh; Kukačka, Zdeněk; Kater, Lukas; Chaplin, Amanda K; Beckmann, Roland; Ascher, David B; Novák, Petr; Blundell, Tom L

Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe(IV) =O Formation

连续飞秒零剂量晶体学捕获染料脱色过氧化物酶中无水远端血红素位点,揭示精氨酸在 Fe(IV) =O 形成中的催化作用

Lučić, Marina; Svistunenko, Dimitri A; Wilson, Michael T; Chaplin, Amanda K; Davy, Bradley; Ebrahim, Ali; Axford, Danny; Tosha, Takehiko; Sugimoto, Hiroshi; Owada, Shigeki; Dworkowski, Florian S N; Tews, Ivo; Owen, Robin L; Hough, Michael A; Worrall, Jonathan A R

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

在通过非同源末端连接修复DNA双链断裂的多组分复合物中,存在可药物结合位点。

Kefala Stavridi, Antonia; Appleby, Robert; Liang, Shikang; Blundell, Tom L; Chaplin, Amanda K

Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance

基因组学、计算生物学和药物发现助力分枝杆菌感染:对抗耐药性的出现

Munir, Asma; Vedithi, Sundeep Chaitanya; Chaplin, Amanda K; Blundell, Tom L