日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Longitudinal Tumor Size and Survival Modeling for Exposure-Response Analysis of Drugs with Frequent Dose Reductions: Dose Justification of Abemaciclib in Patients with Metastatic Breast Cancer

针对频繁减量药物的暴露-反应分析,采用纵向肿瘤大小和生存模型:阿贝西利在转移性乳腺癌患者中的剂量合理性

Chigutsa, Emmanuel; Chapman, Sonya C; Turner, P Kellie

Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects

拉考沙胺、普瑞巴林和他喷他多对周围神经兴奋性的影响:一项在健康受试者中进行的随机、双盲、安慰剂对照、交叉、多中心试验

Nochi, Zahra; Pia, Hossein; Bloms-Funke, Petra; Boesl, Irmgard; Caspani, Ombretta; Chapman, Sonya C; Di Pietro, Giuseppe; Fardo, Francesca; Genser, Bernd; Goetz, Marcus; Jiang, Bo; Kostenko, Anna V; Lebrun, Louisien; Leone, Caterina M; Li, Thomas; Möller-Grell, Niko; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn, Esther; Rong, Clarence; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Tracey, Irene; Truini, Andrea; Vincent, Katy; Vollert, Jan; Wanigasekera, Vishvarani; Wittayer, Matthias; Treede, Rolf-Detlef; Tankisi, Hatice; Finnerup, Nanna B

Abemaciclib in combination with therapies for patients with metastatic breast cancer: a phase 1b study

阿贝西利联合其他疗法治疗转移性乳腺癌患者:一项 1b 期研究

Tolaney, Sara M; Jhaveri, Komal; Helsten, Teresa; Puhalla, Shannon L; Conlin, Alison; Dees, E Claire; Beeram, Muralidhar; Chapman, Sonya C; Lithio, Andrew; Litchfield, Lacey M; Goetz, Matthew P

Application of Physiologically-Based Pharmacokinetic Modeling to Support Drug Labeling: Prediction of CYP3A4-Mediated Pirtobrutinib-Drug Interactions

应用生理药代动力学模型支持药物标签:预测CYP3A4介导的吡托布替尼药物相互作用

Tian, Dan-Dan; Hall, Stephen D; Chapman, Sonya C; Posada, Maria M

Efficacy and safety of abemaciclib alone and with PI3K/mTOR inhibitor LY3023414 or galunisertib versus chemotherapy in previously treated metastatic pancreatic adenocarcinoma: A randomized controlled trial

在既往接受过治疗的转移性胰腺腺癌患者中,阿贝西利单药治疗以及联合PI3K/mTOR抑制剂LY3023414或galunisertib治疗与化疗相比的疗效和安全性:一项随机对照试验

Chiorean, E Gabriela; Picozzi, Vincent; Li, Chung-Pin; Peeters, Marc; Maurel, Joan; Singh, Jaswinder; Golan, Talia; Blanc, Jean-Frédéric; Chapman, Sonya C; Hussain, Anwar M; Johnston, Erica L; Hochster, Howard S

Abemaciclib in combination with pembrolizumab for HR+, HER2- metastatic breast cancer: Phase 1b study

阿贝西利联合帕博利珠单抗治疗HR+、HER2-转移性乳腺癌:1b期研究

Rugo, Hope S; Kabos, Peter; Beck, J Thad; Jerusalem, Guy; Wildiers, Hans; Sevillano, Elena; Paz-Ares, Luis; Chisamore, Michael J; Chapman, Sonya C; Hossain, Anwar M; Chen, Yanyun; Tolaney, Sara M

Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development

药理学探针用于验证镇痛药物研发中的生物标志物

van Niel, Johannes; Bloms-Funke, Petra; Caspani, Ombretta; Cendros, Jose Maria; Garcia-Larrea, Luis; Truini, Andrea; Tracey, Irene; Chapman, Sonya C; Marco-Ariño, Nicolás; Troconiz, Iñaki F; Phillips, Keith; Finnerup, Nanna Brix; Mouraux, André; Treede, Rolf-Detlef

An open label, randomized phase 2 trial assessing the impact of food on the tolerability of abemaciclib in patients with advanced breast cancer

一项开放标签、随机 II 期试验,旨在评估食物对晚期乳腺癌患者服用阿贝西利耐受性的影响

Lim, Elgene; Boyle, Frances; Okera, Meena; Loi, Sherene; Goksu, Sema Sezgin; van Hal, Gertjan; Chapman, Sonya C; Gable, Jonathon Colby; Chen, Yanyun; Price, Gregory L; Hossain, Anwar M; Gainford, M Corona; Ezquerra, Meritxell Bellet

IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)

IMI2-PainCare-BioPain-RCT1:一项随机、双盲、安慰剂对照、交叉、多中心试验的研究方案,旨在研究拉考沙胺、普瑞巴林和他喷他多对通过周围神经兴奋性测试 (NET) 观察到的疼痛处理生物标志物的影响,受试者为健康人群。

Nochi, Zahra; Pia, Hossein; Bloms-Funke, Petra; Boesl, Irmgard; Caspani, Ombretta; Chapman, Sonya C; Fardo, Francesca; Genser, Bernd; Goetz, Marcus; Kostenko, Anna V; Leone, Caterina; Li, Thomas; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn, Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Stouffs, Alexandre; Tracey, Irene; Troconiz, Iñaki F; Truini, Andrea; Van Niel, Johannes; Vela, Jose Miguel; Vincent, Katy; Vollert, Jan; Wanigasekera, Vishvarani; Wittayer, Matthias; Tankisi, Hatice; Finnerup, Nanna B; Phillips, Keith G; Treede, Rolf-Detlef

IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

IMI2-PainCare-BioPain-RCT2方案:一项在健康受试者中进行的随机、双盲、安慰剂对照、交叉、多中心试验,旨在研究拉考沙胺、普瑞巴林和他喷他多对疼痛处理生物标志物的影响,这些生物标志物通过对人类脊髓和脑干活动的非侵入性神经生理测量来观察。

Leone, Caterina; Di Stefano, Giulia; Di Pietro, Giuseppe; Bloms-Funke, Petra; Boesl, Irmgard; Caspani, Ombretta; Chapman, Sonya C; Finnerup, Nanna Brix; Garcia-Larrea, Luis; Li, Tom; Goetz, Marcus; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn, Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Tracey, Irene; Troconiz, Inaki F; Van Niel, Hans; Hernandez, Jose Miguel Vela; Vincent, Katy; Vollert, Jan; Wanigasekera, Vishvarani; Wittayer, Matthias; Phillips, Keith G; Truini, Andrea; Treede, Rolf-Detlef