日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity

设计具有改进的体外ADME特性和降低的hERG亲和力的高效Menin-KMT2A相互作用抑制剂

Chapsal, Bruno D; Kimbrough, Jennifer R; Bester, Stephanie M; Bergstrom, Alex; Backos, Donald S; Campos, Bismarck; McDonald, Matthew G; Abrahamsen, Rebecca; Allen, Andrew C; Doerner Barbour, Patrick M; Bettendorf, Tanna; Boys, Mark L; Brown, Karin; Chicarelli, Mark J; Cook, Adam W; Crooks, Amy L; Cruz, Cole L; Dahlke, Joshua R; Eide, Alida; Fell, Jay B; Fulton, Jennifer L; Gargus, Matthew; Gaudino, John J; Guarnieri, Anna L; Hansen, Erik P; Holt, Melissa C; Kahn, Dean R; Laird, Ellen R; Larsen, Paul D; Linwood, Rebecca; Martinson, Matthew C; McCown, Joseph; Mejia, Macedonio J; Moreno, David A; Mou, Tung-Chung; Newhouse, Brad; O'Leary, Jacob M; Rodriguez, Martha E; Singh, Anurag; Sinik, Lenka; Strand, Keith A; Touney, Eric E; Wollenberg, Lance A; Wong, Jim; Zhou, Yeyun; Fischer, John P; Allen, Shelley

Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors

发现5-氮杂喹喔啉衍生物作为高效且口服生物利用度高的变构SHP2抑制剂

Elsayed, Mohamed S A; Blake, James F; Boys, Mark L; Brown, Eric; Chapsal, Bruno D; Chicarelli, Mark J; Cook, Adam W; Fell, Jay B; Fischer, John P; Hanson, Lauren; Lemieux, Christine; Martinson, Matthew C; McCown, Joseph; McNulty, Oren T; Mejia, Macedonio J; Neitzel, Nickolas A; Otten, Jennifer N; Rodriguez, Martha E; Wilcox, Daniel; Wong, Christina E; Zhou, Yeyun; Hinklin, Ronald J

Animal testing for vaccines. Implementing replacement, reduction and refinement: challenges and priorities

疫苗动物试验。实施替代、减少和改进:挑战与优先事项

Akkermans, Arnoud; Chapsal, Jean-Michel; Coccia, Eliana M; Depraetere, Hilde; Dierick, Jean-François; Duangkhae, Parichat; Goel, Sunil; Halder, Marlies; Hendriksen, Coenraad; Levis, Robin; Pinyosukhee, Koraphong; Pullirsch, Dieter; Sanyal, Gautam; Shi, Li; Sitrin, Robert; Smith, Dean; Stickings, Paul; Terao, Eriko; Uhlrich, Sylvie; Viviani, Laura; Webster, Jim

Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors

取代基对 P2-环戊基四氢呋喃基氨基甲酸酯的影响:强效 HIV-1 蛋白酶抑制剂的设计、合成和 X 射线研究

Ghosh, Arun K; Chapsal, Bruno D; Steffey, Melinda; Agniswamy, Johnson; Wang, Yuan-Fang; Amano, Masayuki; Weber, Irene T; Mitsuya, Hiroaki

Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors

设计和合成具有明确立体化学结构的新型螺环P2配体用于HIV-1蛋白酶抑制剂

Ghosh, Arun K; Chapsal, Bruno D; Baldridge, Abigail; Ide, Kazuhiko; Koh, Yashiro; Mitsuya, Hiroaki

Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation

利用高效钯催化不对称烯丙基烷基化反应全合成对映体纯的(+)-γ-石蒜烷

Chapsal, Bruno D; Ojima, Iwao