日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

非小胶质细胞中 PLCG2 的下调会损害突触功能,并引发阿尔茨海默病相关的特征。

Coulon Audrey, Rabiller Florian, Takalo Mari, Roy Avishek, Pelletier Alexandre, Martiskainen Henna, Siedlecki-Wullich Dolores, Lannette-Weimann Nina, Majerníková Nad'a, Grenon Arthur, Gao Vance, Erhardt Anaël, Pernodet Anne, Lemaire Morgane, Limoge Floriane, Walle Pauline, Mendes Tiago, Guyot Karine, Lemeu Célia, Carvalho Lukas-Iohan, de Farias Ana Raquel Melo, Hulsman Marc, Najdek Chloé, Freire-Regatillo Alejandra, Saha Orthis, Amouyel Philippe, Charbonnier Camille, Deleuze Jean-François, Dols-Icardo Orio, Jeskanen Heli, Willman Roosa-Maria, Kuulasmaa Teemu, Kurki Mitja, Hardy John, Heikkinen Sami, Holstege Henne, Mäkinen Petra, Nicolas Gaël, Mead Simon, Wagner Michael, Ramirez Alfredo, Rauramaa Tuomas, Palotie Aarno, Sims Rebecca, Soininen Hilkka, van Swieten John, Williams Julie, Bellenguez Céline, Gelle Carla, Lambert Erwan, Costa Marcos R, Tcw Julia, Glaab Enrico, Ayral Anne-Marie, Demiautte Florie, Grenier-Boley Benjamin, Muntaner Manon, Eberlé Delphine, Deforges Séverine, Haas Joel, Kilinc Devrim, Mulle Christophe, Chapuis Julien, Hiltunen Mikko, Dumont Julie, Lambert Jean-Charles

The structure of an amyloid precursor protein/talin complex indicates a mechanical basis of Alzheimer's disease.

淀粉样前体蛋白/肌动蛋白复合物的结构表明阿尔茨海默病具有机械基础

Ellis Charles, Ward Natasha L, Rice Matthew, Ball Neil J, Walle Pauline, Najdek Chloé, Kilinc Devrim, Lambert Jean-Charles, Chapuis Julien, Goult Benjamin T

Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

更正:阿尔茨海默病遗传风险因子FERMT2(Kindlin-2)以APP依赖的方式控制轴突生长和突触可塑性

Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anaїs-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Chécler, Frédéric; Farinelli, Mélissa; Delay, Charlotte; Malmanche, Nicolas; Hébert, Sébastien S; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien

The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

阿尔茨海默病的新遗传图谱:从淀粉样蛋白级联到基因驱动的突触功能障碍假说?

Dourlen, Pierre; Kilinc, Devrim; Malmanche, Nicolas; Chapuis, Julien; Lambert, Jean-Charles

Open-CSAM, a new tool for semi-automated analysis of myofiber cross-sectional area in regenerating adult skeletal muscle

Open-CSAM,一种用于半自动分析成人骨骼肌再生肌纤维横截面积的新工具

Thibaut Desgeorges, Sophie Liot, Solene Lyon, Jessica Bouvière, Alix Kemmel, Aurélie Trignol, David Rousseau, Bruno Chapuis, Julien Gondin, Rémi Mounier, Bénédicte Chazaud, Gaëtan Juban

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

利用高通量动物或细胞模型对全基因组关联研究信号进行功能表征

Dourlen, Pierre; Chapuis, Julien; Lambert, Jean-Charles

Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.

全基因组高通量 siRNA 筛选发现阿尔茨海默病遗传风险因子 FERMT2 是 APP 代谢的主要调节因子

Chapuis Julien, Flaig Amandine, Grenier-Boley Benjamin, Eysert Fanny, Pottiez Virginie, Deloison Gaspard, Vandeputte Alexandre, Ayral Anne-Marie, Mendes Tiago, Desai Shruti, Goate Alison M, Kauwe John S K, Leroux Florence, Herledan Adrien, Demiautte Florie, Bauer Charlotte, Checler Fréderic, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee, Shaw Leslie M, Trojanowski John Q, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Peskind Elaine R, Malmanche Nicolas, Schellenberg Gerard D, Dourlen Pierre, Song Ok-Ryul, Cruchaga Carlos, Amouyel Philippe, Deprez Benoit, Brodin Priscille, Lambert Jean-Charles

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain

Tau蛋白磷酸化调节BIN1的SH3结构域与Tau蛋白富含脯氨酸结构域之间的相互作用。

Sottejeau, Yoann; Bretteville, Alexis; Cantrelle, François-Xavier; Malmanche, Nicolas; Demiaute, Florie; Mendes, Tiago; Delay, Charlotte; Alves Dos Alves, Harmony; Flaig, Amandine; Davies, Peter; Dourlen, Pierre; Dermaut, Bart; Laporte, Jocelyn; Amouyel, Philippe; Lippens, Guy; Chapuis, Julien; Landrieu, Isabelle; Lambert, Jean-Charles

Determinants of gain modulation enabled by short-term depression at an inhibitory cerebellar synapse

小脑抑制性突触短期抑制所实现的增益调节的决定因素

Siedlecki-Wullich, Dolores; Ayral, Anne-Marie; Iohan, Lukas; Lemeu, Célia; Buiche, Valérie; Blary, Karine; Chapuis, Julien; Eysert, Fanny; Beury, Delphine; Delacre, Myriam; Hot, David; Masuda, Takahiro; Knobeloch, Klaus-Peter; Prinz, Marco; Lambert, Jean-Charles; Kilinc, Devrim; Bampasakis, Dimitris; Maex, Reinoud; Davey, Neil; Steuber, Volker

Gas1 interferes with AβPP trafficking by facilitating the accumulation of immature AβPP in endoplasmic reticulum-associated raft subdomains.

Gas1 通过促进未成熟的 AβPP 在内质网相关筏亚结构域中的积累来干扰 AβPP 的运输

Chapuis Julien, Vingtdeux Valérie, Capiralla Hemachander, Davies Peter, Marambaud Philippe