日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis

一项针对晚期骨髓纤维化的新型泛赖氨酰氧化酶抑制剂 PXS-5505 的 I/IIa 期试验

Vachhani, Pankit; Tan, Peter; Watson, Anne-Marie; Wu, Shang-Ju; Baker, Ross; Cheung, Stanley; Lee, Sung-Eun; Chen, Chih-Cheng; Chen, Tsai-Yun; Hsiao, Hui-Hua; Lee, Jae Hoon; Masarova, Lucia; Tan, Shuh Ying; Baskar, Jana; Charlton, Brett; Findlay, Alison; Hamprecht, Dieter; Jarolimek, Wolfgang; Leadbetter, Joanna; Miller, John; Morgan, Kristen; Zahoor, Amna; Hobbs, Gabriela

The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement.

小分子 LOXL2 抑制剂 SNT-5382 可减少心脏纤维化,并实现强大的临床靶点结合

Perryman Lara, Findlay Alison, Baskar Jana, Charlton Brett, Foot Jonathan, Hamilton Ross, Hamprecht Dieter, Joshi Amar, Stolp Jessica, Turner Craig, Zahoor Amna, Zhou Wenbin, López Begoña, Ravassa Susana, González Arantxa, Jarolimek Wolfgang

An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies

一种基于活性的生物探针能够区分新型小分子抑制剂和LOXL2抗体,并为抗纤维化治疗策略带来新的希望。

Findlay, Alison; Turner, Craig; Schilter, Heidi; Deodhar, Mandar; Zhou, Wenbin; Perryman, Lara; Foot, Jonathan; Zahoor, Amna; Yao, Yimin; Hamilton, Ross; Brock, Mary; Raso, Christina; Stolp, Jessica; Galati, Marie; Hamprecht, Dieter; Charlton, Brett; Jarolimek, Wolfgang

Optimising inhaled mannitol for cystic fibrosis in an adult population

优化成人囊性纤维化患者吸入甘露醇的治疗

Flume, Patrick A; Aitken, Moira L; Bilton, Diana; Agent, Penny; Charlton, Brett; Forster, Emma; Fox, Howard G; Hebestreit, Helge; Kolbe, John; Zuckerman, Jonathan B; Button, Brenda M

Inspiratory flows and volumes in subjects with cystic fibrosis using a new dry powder inhaler device

使用新型干粉吸入器装置治疗囊性纤维化患者的吸气流速和吸气量

Elkins, Mark R; Robinson, Philip; Anderson, Sandra D; Perry, Clare P; Daviskas, Evangelia; Charlton, Brett

Inspiratory Flows and Volumes in Subjects with Non-CF Bronchiectasis Using a New Dry Powder Inhaler Device

使用新型干粉吸入器装置治疗非囊性纤维化支气管扩张症患者的吸气流速和吸气量

Elkins, Mark R; Anderson, Sandra D; Perry, Clare P; Daviskas, Evangelia; Charlton, Brett