日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D(2) Receptor.

鉴定多巴胺 D(2) 受体正变构调节剂的脂质暴露螺旋外结合位点

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00105
Lim Herman D, Bartuzi Damian, Keen Alastair C, Rauffenbart Caroline, Glenn Jacqueline, Charlton Steven J, Lovera Silvia, Sands Zara A, Ates Ali, Wood Martyn, Canals Meritxell, Javitch Jonathan A, Carlsson Jens, Lane J Robert
信号转导
发表日期：2025
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Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting β(2)-adrenoceptor agonist, indacaterol, in human airway epithelial cells.

卡巴胆碱（一种毒蕈碱受体激动剂）与长效β2-肾上腺素受体激动剂茚达特罗在人类呼吸道上皮细胞中的基因组串扰

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1016/j.jpet.2025.103579
Jayasinghe Varuna, Joshi Radhika, Joshi Taruna, Paracha Tamkeen U, Kooi Cora, Mostafa Mahmoud M, Bauer Carla M T, Charlton Steven J, Iartchouk Oleg, Maillet Ashley, Morris Melody K, Ruda Vera M, Sandham David A, Wang Yanqun, Newton Robert, Giembycz Mark A
细胞生物学
Human
发表日期：2025
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Exploring the kinetic selectivity of drugs targeting the β(1) -adrenoceptor

探索靶向β(1)-肾上腺素受体的药物的动力学选择性

期刊:Pharmacology Research & Perspectives
影响因子:2.3
doi:10.1002/prp2.978
Sykes, David A; Jiménez-Rosés, Mireia; Reilly, John; Fairhurst, Robin A; Charlton, Steven J; Veprintsev, Dmitry B
信号转导
免疫/内分泌
发表日期：2022
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Reply to 'Antipsychotics with similar association kinetics at dopamine D(2) receptors differ in extrapyramidal side-effects'

回复“与多巴胺D(2)受体结合动力学相似的抗精神病药物在锥体外系副作用方面存在差异”

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-018-05678-4
Sykes, David A; Lane, J Robert; Szabo, Monika; Capuano, Ben; Javitch, Jonathan A; Charlton, Steven J
信号转导
发表日期：2018
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Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

预组装的GPCR信号复合物介导细胞对超低配体浓度的不同反应

期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.aan1188
Civciristov, Srgjan; Ellisdon, Andrew M; Suderman, Ryan; Pon, Cindy K; Evans, Bronwyn A; Kleifeld, Oded; Charlton, Steven J; Hlavacek, William S; Canals, Meritxell; Halls, Michelle L
信号转导
细胞生物学
GPCR/Calcium/cAMP
发表日期：2018
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Airway remodeling disease: primary human structural cells and phenotypic and pathway assays to identify targets with potential to prevent or reverse remodeling

气道重塑疾病：利用原代人结构细胞、表型和通路分析来识别具有预防或逆转重塑潜力的靶点

期刊:Journal of Experimental Pharmacology
影响因子:
doi:10.2147/JEP.S159124
Rosethorne, Elizabeth M; Charlton, Steven J
信号转导
细胞生物学
发表日期：2018
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Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization

研究FTY720-P引起S1P1受体持续内化的分子机制

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1111/bph.12620
Sykes, David A; Riddy, Darren M; Stamp, Craig; Bradley, Michelle E; McGuiness, Neil; Sattikar, Afrah; Guerini, Danilo; Rodrigues, Ines; Glaenzel, Albrecht; Dowling, Mark R; Mullershausen, Florian; Charlton, Steven J
信号转导
发表日期：2014
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High coverage fluid-phase floating lipid bilayers supported by ω-thiolipid self-assembled monolayers

由 ω-硫代脂质自组装单分子膜支撑的高覆盖率液相浮动脂质双层

期刊:Journal of the Royal Society Interface
影响因子:3.7
doi:10.1098/rsif.2014.0447
Arwel V Hughes, Stephen A Holt, Emma Daulton, Andrei Soliakov, Timothy R Charlton, Steven J Roser, Jeremy H Lakey
发表日期：2014
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High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function

利用高通量诱变技术鉴定调控人前列环素（hIP）受体表达和功能的残基

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0097973
Bill, Anke; Rosethorne, Elizabeth M; Kent, Toby C; Fawcett, Lindsay; Burchell, Lynn; van Diepen, Michiel T; Marelli, Anthony; Batalov, Sergey; Miraglia, Loren; Orth, Anthony P; Renaud, Nicole A; Charlton, Steven J; Gosling, Martin; Gaither, L Alex; Groot-Kormelink, Paul J
信号转导
发表日期：2014
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Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays

难以捉摸的平衡：利用钙测定法解读受体药理学的挑战

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1111/j.1476-5381.2010.00863.x
Charlton, Steven J; Vauquelin, Georges
信号转导
发表日期：2010
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