日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Absolute quantification of mammalian microRNAs for therapeutic RNA cleavage and detargeting.

哺乳动物microRNA的绝对定量,用于治疗性RNA切割和脱靶

Kraus Carolyn, Wang Jiayi, Zheng Haiying, Broderick Jennifer, Ajaykumar Nandagopal, Zamani Mina, Yang Mengqi, Cecchini Katharine, Liang Shun-Qing, Kolumba Olena, Chase Kathryn, Lee Jooyoung, Xue Wen, Sontheimer Erik J, Gainetdinov Ildar

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

突变型亨廷顿蛋白信使RNA在啮齿动物和人类大脑中形成神经元核簇

Ly, Socheata; Didiot, Marie-Cécile; Ferguson, Chantal M; Coles, Andrew H; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia

Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities

通过编码区单核苷酸多态性杂合性编辑实现突变亨廷顿蛋白的等位基因特异性敲低

Oikemus, Sarah R; Pfister, Edith L; Sapp, Ellen; Chase, Kathryn O; Kennington, Lori A; Hudgens, Edward; Miller, Rachael; Zhu, Lihua Julie; Chaudhary, Akanksh; Mick, Eric O; Sena-Esteves, Miguel; Wolfe, Scot A; DiFiglia, Marian; Aronin, Neil; Brodsky, Michael H

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

代谢应激反应中,cJun氨基末端激酶3调节AgRP神经元的兴奋性传递。

Vernia, Santiago; Morel, Caroline; Madara, Joseph C; Cavanagh-Kyros, Julie; Barrett, Tamera; Chase, Kathryn; Kennedy, Norman J; Jung, Dae Young; Kim, Jason K; Aronin, Neil; Flavell, Richard A; Lowell, Bradford B; Davis, Roger J

A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo

一种用于直接检测体内治疗性寡核苷酸诱导基因沉默的高通量方法

Coles, Andrew H; Osborn, Maire F; Alterman, Julia F; Turanov, Anton A; Godinho, Bruno M D C; Kennington, Lori; Chase, Kathryn; Aronin, Neil; Khvorova, Anastasia

Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity

突变型亨廷顿蛋白通过干扰Rab11活性,损害由循环内体形成的囊泡。

Li, Xueyi; Standley, Clive; Sapp, Ellen; Valencia, Antonio; Qin, Zheng-Hong; Kegel, Kimberly B; Yoder, Jennifer; Comer-Tierney, Laryssa A; Esteves, Miguel; Chase, Kathryn; Alexander, Jonathan; Masso, Nicholas; Sobin, Lindsay; Bellve, Karl; Tuft, Richard; Lifshitz, Lawrence; Fogarty, Kevin; Aronin, Neil; DiFiglia, Marian