ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene
ERK1/2 直接作用于 CTGF/CCN2 的表达,从而介导由层粘蛋白 A/C 基因突变引起的心肌病中的心肌纤维化。
期刊:Human Molecular Genetics
影响因子:3.2
doi:10.1093/hmg/ddw090
Chatzifrangkeskou, Maria; Le Dour, Caroline; Wu, Wei; Morrow, John P; Joseph, Leroy C; Beuvin, Maud; Sera, Fusako; Homma, Shunichi; Vignier, Nicolas; Mougenot, Nathalie; Bonne, Gisèle; Lipson, Kenneth E; Worman, Howard J; Muchir, Antoine