De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one
在两例新发现的散发性林奇综合征病例中,新生MLH1表观遗传突变导致早发性结直肠癌,其中一例的表观遗传突变来源于父系等位基因。
期刊:International Journal of Cancer
影响因子:4.7
doi:10.1002/ijc.25422
Goel, Ajay; Nguyen, Thuy-Phuong; Leung, Hon-Chiu E; Nagasaka, Takeshi; Rhees, Jennifer; Hotchkiss, Erin; Arnold, Mildred; Banerji, Pia; Koi, Minoru; Kwok, Chau-To; Packham, Deborah; Lipton, Lara; Boland, C Richard; Ward, Robyn L; Hitchins, Megan P