Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound
发现 2-(2-苯并恶唑基氨基)-4-芳基-5-氰基嘧啶作为代谢型谷氨酸受体 5 (mGlu₅) 的负变构调节剂 (NAM)：从人工神经网络虚拟筛选到体内工具化合物
期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.201100510
Mueller, Ralf; Dawson, Eric S; Meiler, Jens; Rodriguez, Alice L; Chauder, Brian A; Bates, Brittney S; Felts, Andrew S; Lamb, Jeffrey P; Menon, Usha N; Jadhav, Sataywan B; Kane, Alexander S; Jones, Carrie K; Gregory, Karen J; Niswender, Colleen M; Conn, P Jeffrey; Olsen, Christopher M; Winder, Danny G; Emmitte, Kyle A; Lindsley, Craig W
