The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication
咪唑并吡咯并吡啶类似物AG110是一种新型的高选择性瘟病毒抑制剂,它靶向病毒RNA依赖性RNA聚合酶的关键位点,从而抑制病毒复制。
期刊:Journal of Virology
影响因子:3.8
doi:10.1128/JVI.00388-07
Paeshuyse, Jan; Chezal, Jean-Michel; Froeyen, Matheus; Leyssen, Pieter; Dutartre, Hélène; Vrancken, Robert; Canard, Bruno; Letellier, Carine; Li, Tong; Mittendorfer, Harald; Koenen, Frank; Kerkhofs, Pierre; De Clercq, Erik; Herdewijn, Piet; Puerstinger, Gerhard; Gueiffier, Alain; Chavignon, Olivier; Teulade, Jean-Claude; Neyts, Johan