日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A druggable redox switch on SHP1 controls macrophage inflammation

SHP1 上的可药物调控的氧化还原开关控制巨噬细胞炎症

Ng, Mei Ying; Nix, Meredith N; Du, Guangyan; Davidek, Ivan; Burger, Nils; Shin, Sanghee; Toenjes, Sean; Takeda, Haruna; Cheah Xin Yan, Megan; Zhang, Bingsen; Xiao, Haopeng; Wei, Shelley M; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Wales, Thomas E; Engen, John R; Mills, Evanna L; Che, Jianwei; Zhang, Tinghu; Gray, Nathanael S; Chouchani, Edward T

An AKR1C3-activated kinase inhibitor prodrug.

AKR1C3激活激酶抑制剂前药。

Li Zhengnian, Martinez Michael, Byun Woong Sub, Thathireddy Anuradha, Qiu Tian, Wang Yaning, Katzengruber Leon, Chouldjian Ani, Lu Wenchao, Ji Wenzhi, Che Jianwei, Zhang Tinghu, Hinshaw Stephen M, Gray Nathanael S

The human zinc-binding cysteine proteome.

人类锌结合半胱氨酸蛋白质组

Burger Nils, Mittenbühler Melanie J, Xiao Haopeng, Shin Sanghee, Wei Shelley M, Henze Erik K, Schindler Sebastian, Mehravar Sepideh, Wood David M, Petrocelli Jonathan J, Sun Yizhi, Sprenger Hans-Georg, Latorre-Muro Pedro, Smythers Amanda L, Bozi Luiz H M, Darabedian Narek, Zhu Yingde, Seo Hyuk-Soo, Dhe-Paganon Sirano, Che Jianwei, Chouchani Edward T

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

扩大可成药锌指蛋白组,可以明确药物诱导降解的特性

Słabicki Mikołaj, Park Jiho, Nowak Radosław P, Roy Burman Shourya S, Pellman Jesse, Zou Charles, Razumkov Hlib, Carreiro Jeannie, Rastogi Simran, Goldstein Anna, Nagiec Marek M, Donovan Katherine A, Che Jianwei, Hunkeler Moritz, Geng Qixiang, Hsu Chi-Lin, Lakshminarayan Megha, Shu Chelsea, Zon Rebecca L, Kozicka Zuzanna, Park Paul M C, Tsai Jonathan M, Yoon Hojong, Jones Lyn H, Sperling Adam S, Gray Nathanael S, Fischer Eric S, Ebert Benjamin L

Unveiling the hidden interactome of CRBN molecular glues.

揭示 CRBN 分子胶的隐藏相互作用组

Baek Kheewoong, Metivier Rebecca J, Roy Burman Shourya S, Bushman Jonathan W, Yoon Hojong, Lumpkin Ryan J, Ryan Julia K, Abeja Dinah M, Lakshminarayan Megha, Yue Hong, Ojeda Samuel, Xiong Yuan, Che Jianwei, Verano Alyssa L, Schmoker Anna M, Gray Nathanael S, Donovan Katherine A, Fischer Eric S

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7).

泛素特异性蛋白酶 7 (USP7) 的小分子变构激活剂。

Jaen Maisonet Isabella, Sharafi Mona, Korchak Emilie J, Salazar-Chaparro Andres, Bratt Ariana S, Parikh Tvesha, Varca Anthony C, Shah Binita, Darnowski Michael, Chung Mia, Teh Wei Pin, Che Jianwei, Bezsonova Irina, Buhrlage Sara J

Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α

基于结构的截短型异二价化学探针IRE1α降解剂的设计

Zerfas, Breanna L; Liu, Yingpeng; Che, Jianwei; Donovan, Katherine A; Hatcher, John M; Huerta, Fidel; Metivier, Rebecca J; Nowak, Radosław P; Ragosta, Leah; Tsang, Tiffany; Fischer, Eric S; Jones, Lyn H

Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775

通过靶向Cys775的单价和双齿抑制剂克服EGFR耐药性

Li, Zhengnian; Jiang, Jie; Wang, Yaning; Ficarro, Scott B; Collins, Stephen J; Beyett, Tyler S; Schaeffner, Ilse K; Tavares, Isidoro; Gottlieb, Felix H; Suda, Dhiraj; Gokhale, Prafulla C; Black-Holmes, Leah M; Gazgalis, Dimitris; Eck, Michael J; Jänne, Pasi A; Marto, Jarrod A; Che, Jianwei; Gray, Nathanael S; Zhang, Tinghu

Positive Selection Screen for Natural Product β-Catenin Inactivators

天然产物β-catenin失活剂的阳性选择筛选

Boudreau, Matthew W; Freire, Vitor F; Corbett, Sophie C; Martínez-Fructuoso, Lucero; Kumar, Rohitesh; Thornburg, Christopher C; Akee, Rhone K; Peyser, Brian D; Jiang, Qinqin; Splaine, Jennifer; Pfaff, Jamie L; Chandler, Benjamin C; Abeja, Dinah M; Donovan, Katherine A; Che, Jianwei; Lampson, Benjamin L; Szajner, Patricia; Smith, Jennifer A; Koduri, Vidyasagar; Grkovic, Tanja; O'Keefe, Barry R; Kaelin, William G Jr

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

具有两个亲电弹头的分子双螺旋结构作为一种新型药理学模式

Li, Zhengnian; Jiang, Jie; Ficarro, Scott B; Beyett, Tyler S; To, Ciric; Tavares, Isidoro; Zhu, Yingde; Li, Jiaqi; Eck, Michael J; Jänne, Pasi A; Marto, Jarrod A; Zhang, Tinghu; Che, Jianwei; Gray, Nathanael S