日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

快速诱导多能干细胞包涵体病模型揭示了α-突触核蛋白包涵体的形成、后果和分子亚型

Lam, Isabel; Ndayisaba, Alain; Lewis, Amanda J; Fu, YuHong; Sagredo, Giselle T; Kuzkina, Anastasia; Zaccagnini, Ludovica; Celikag, Meral; Sandoe, Jackson; Sanz, Ricardo L; Vahdatshoar, Aazam; Martin, Timothy D; Morshed, Nader; Ichihashi, Toru; Tripathi, Arati; Ramalingam, Nagendran; Oettgen-Suazo, Charlotte; Bartels, Theresa; Boussouf, Manel; Schäbinger, Max; Hallacli, Erinc; Jiang, Xin; Verma, Amrita; Tea, Challana; Wang, Zichen; Hakozaki, Hiroyuki; Yu, Xiao; Hyles, Kelly; Park, Chansaem; Wang, Xinyuan; Theunissen, Thorold W; Wang, Haoyi; Jaenisch, Rudolf; Lindquist, Susan; Stevens, Beth; Stefanova, Nadia; Wenning, Gregor; van de Berg, Wilma D J; Luk, Kelvin C; Sanchez-Pernaute, Rosario; Gómez-Esteban, Juan Carlos; Felsky, Daniel; Kiyota, Yasujiro; Sahni, Nidhi; Yi, S Stephen; Chung, Chee Yeun; Stahlberg, Henning; Ferrer, Isidro; Schöneberg, Johannes; Elledge, Stephen J; Dettmer, Ulf; Halliday, Glenda M; Bartels, Tim; Khurana, Vikram

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

快速诱导多能干细胞包涵体病模型揭示了α-突触核蛋白包涵体的形成、后果和分子亚型

Isabel Lam ,Alain Ndayisaba ,Amanda J Lewis ,YuHong Fu ,Giselle T Sagredo ,Anastasia Kuzkina ,Ludovica Zaccagnini ,Meral Celikag ,Jackson Sandoe ,Ricardo L Sanz ,Aazam Vahdatshoar ,Timothy D Martin ,Nader Morshed ,Toru Ichihashi ,Arati Tripathi ,Nagendran Ramalingam ,Charlotte Oettgen-Suazo ,Theresa Bartels ,Manel Boussouf ,Max Schäbinger ,Erinc Hallacli ,Xin Jiang ,Amrita Verma ,Challana Tea ,Zichen Wang ,Hiroyuki Hakozaki ,Xiao Yu ,Kelly Hyles ,Chansaem Park ,Xinyuan Wang ,Thorold W Theunissen ,Haoyi Wang ,Rudolf Jaenisch ,Susan Lindquist ,Beth Stevens ,Nadia Stefanova ,Gregor Wenning ,Wilma D J van de Berg ,Kelvin C Luk ,Rosario Sanchez-Pernaute ,Juan Carlos Gómez-Esteban ,Daniel Felsky ,Yasujiro Kiyota ,Nidhi Sahni ,S Stephen Yi ,Chee Yeun Chung ,Henning Stahlberg ,Isidro Ferrer ,Johannes Schöneberg ,Stephen J Elledge ,Ulf Dettmer ,Glenda M Halliday ,Tim Bartels ,Vikram Khurana

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models

靶向从头脂质合成会诱导胶质母细胞瘤小鼠模型出现脂毒性并损害DNA损伤修复。

Eyme, Katharina M; Sammarco, Alessandro; Jha, Roshani; Mnatsakanyan, Hayk; Pechdimaljian, Caline; Carvalho, Litia; Neustadt, Rudolph; Moses, Charlotte; Alnasser, Ahmad; Tardiff, Daniel F; Su, Baolong; Williams, Kevin J; Bensinger, Steven J; Chung, Chee Yeun; Badr, Christian E

The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

帕金森病蛋白α-突触核蛋白是加工体和mRNA稳定性的调节因子。

Erinc Hallacli ,Can Kayatekin ,Sumaiya Nazeen ,Xiou H Wang ,Zoe Sheinkopf ,Shubhangi Sathyakumar ,Souvarish Sarkar ,Xin Jiang ,Xianjun Dong ,Roberto Di Maio ,Wen Wang ,Matthew T Keeney ,Daniel Felsky ,Jackson Sandoe ,Aazam Vahdatshoar ,Namrata D Udeshi ,D R Mani ,Steven A Carr ,Susan Lindquist ,Philip L De Jager ,David P Bartel ,Chad L Myers ,J Timothy Greenamyre ,Mel B Feany ,Shamil R Sunyaev ,Chee Yeun Chung ,Vikram Khurana

Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

更正:一种能穿透血脑屏障的硬脂酰辅酶A去饱和酶抑制剂可逆转α-突触核蛋白毒性

Nuber, Silke; Chung, Chee Yeun; Tardiff, Daniel F; Bechade, Pascal A; McCaffery, Thomas D; Shimanaka, Kazuma; Choi, Jeonghoon; Chang, Belle; Raja, Waseem; Neves, Esther; Burke, Christopher; Jiang, Xin; Xu, Ping; Khurana, Vikram; Dettmer, Ulf; Fanning, Saranna; Rhodes, Kenneth J; Selkoe, Dennis J; Scannevin, Robert H

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

脑渗透性硬脂酰辅酶 A 去饱和酶抑制剂可逆转 α-突触核蛋白毒性

Silke Nuber #, Chee Yeun Chung #, Daniel F Tardiff, Pascal A Bechade, Thomas D McCaffery, Kazuma Shimanaka, Jeonghoon Choi, Belle Chang, Waseem Raja, Esther Neves, Christopher Burke, Xin Jiang, Ping Xu, Vikram Khurana, Ulf Dettmer, Saranna Fanning, Kenneth J Rhodes, Dennis J Selkoe, Robert H Scannev

Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson's Disease

YTX-7739 的非临床药理学:一种用于治疗帕金森病的临床阶段硬脂酰辅酶 A 去饱和酶抑制剂

Daniel F Tardiff, Matthew Lucas, Iwona Wrona, Belle Chang, Chee Yeun Chung, Bertrand Le Bourdonnec, Kenneth J Rhodes, Robert H Scannevin

Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease

利用患者来源的三维皮质神经球模拟帕金森病

Waseem K Raja ,Esther Neves ,Christopher Burke ,Xin Jiang ,Ping Xu ,Kenneth J Rhodes ,Vikram Khurana ,Robert H Scannevin ,Chee Yeun Chung

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

基因组规模网络通过特定分子通路将神经退行性疾病基因与 α-突触核蛋白联系起来

Vikram Khurana, Jian Peng, Chee Yeun Chung, Pavan K Auluck, Saranna Fanning, Daniel F Tardiff, Theresa Bartels, Martina Koeva, Stephen W Eichhorn, Hadar Benyamini, Yali Lou, Andy Nutter-Upham, Valeriya Baru, Yelena Freyzon, Nurcan Tuncbag, Michael Costanzo, Bryan-Joseph San Luis, David C Schöndorf, 

Calcineurin determines toxic versus beneficial responses to α-synuclein

钙调磷酸酶决定了α-突触核蛋白的毒性反应与有益反应。

Caraveo, Gabriela; Auluck, Pavan K; Whitesell, Luke; Chung, Chee Yeun; Baru, Valeriya; Mosharov, Eugene V; Yan, Xiaohui; Ben-Johny, Manu; Soste, Martin; Picotti, Paola; Kim, Hanna; Caldwell, Kim A; Caldwell, Guy A; Sulzer, David; Yue, David T; Lindquist, Susan