日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Aided Design of a LuxR-Type Quorum Sensing SuFEx-Based Potential Inhibitor: Covalent or Competitive Inhibition?

基于结构辅助设计的LuxR型群体感应SuFEx潜在抑制剂:共价抑制还是竞争性抑制?

Soulère, Laurent; Reverchon, Sylvie; Baude, Jessica; Chefdeville, Emmanuel; Vauchez, Antoine; Queneau, Yves; Nasser, William

CNS‐active drugs for neuropsychiatric disorders differentially modulate the risk of AD development

用于治疗神经精神疾病的中枢神经系统活性药物对阿尔茨海默病(AD)的发生风险具有不同的调节作用。

Cai, Song; Moutal, Aubin; Yu, Jie; Chew, Lindsey A; Isensee, Jörg; Chawla, Reena; Gomez, Kimberly; Luo, Shizhen; Zhou, Yuan; Chefdeville, Aude; Madura, Cynthia; Perez-Miller, Samantha; Bellampalli, Shreya Sai; Dorame, Angie; Scott, David D; François-Moutal, Liberty; Shan, Zhiming; Woodward, Taylor; Gokhale, Vijay; Hohmann, Andrea G; Vanderah, Todd W; Patek, Marcel; Khanna, May; Hucho, Tim; Khanna, Rajesh; Cortes‐Flores, Helena; Torrandell‐Haro, Georgina; Brinton, Roberta Diaz

A peptidomimetic modulator of the Ca(V)2.2 N-type calcium channel for chronic pain

一种用于治疗慢性疼痛的 Ca(V)2.2 N 型钙通道的肽模拟调节剂

Gomez, Kimberly; Santiago, Ulises; Nelson, Tyler S; Allen, Heather N; Calderon-Rivera, Aida; Hestehave, Sara; Rodríguez Palma, Erick J; Zhou, Yuan; Duran, Paz; Loya-Lopez, Santiago; Zhu, Elaine; Kumar, Upasana; Shields, Rory; Koseli, Eda; McKiver, Bryan; Giuvelis, Denise; Zuo, Wanhong; Inyang, Kufreobong E; Dorame, Angie; Chefdeville, Aude; Ran, Dongzhi; Perez-Miller, Samantha; Lu, Yi; Liu, Xia; Handoko; Arora, Paramjit S; Patek, Marcel; Moutal, Aubin; Khanna, May; Hu, Huijuan; Laumet, Geoffroy; King, Tamara; Wang, Jing; Damaj, M Imad; Korczeniewska, Olga A; Camacho, Carlos J; Khanna, Rajesh

Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain

条件性敲除神经元(而非星形胶质细胞)中的 CRMP2 会破坏脊髓伤害性神经传递,从而控制慢性神经性疼痛的发生和维持

Lisa Boinon, Jie Yu, Cynthia L Madura, Aude Chefdeville, Douglas L Feinstein, Aubin Moutal, Rajesh Khanna

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain

CRMP2 SUMO 化缺陷转基因小鼠研究确定了慢性神经性疼痛发病机制中性别特异性 Nav1.7 调控

Aubin Moutal, Song Cai, Jie Yu, Harrison J Stratton, Aude Chefdeville, Kimberly Gomez, Dongzhi Ran, Cynthia L Madura, Lisa Boinon, Maira Soto, Yuan Zhou, Zhiming Shan, Lindsey A Chew, Kathleen E Rodgers, Rajesh Khanna

Validating indicators of CNS disorders in a swine model of neurological disease

验证猪神经系统疾病模型中中枢神经系统疾病的指标

Vicki J Swier, Katherine A White, David K Meyerholz, Aude Chefdeville, Rajesh Khanna, Jessica C Sieren, Dawn E Quelle, Jill M Weimer

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels

桦木酸是从沙漠薰衣草 Hyptis emoryi 中提取的,可通过阻断 N 型和 T 型钙通道来减轻紫杉醇、HIV 和神经损伤相关的周围感觉神经病变

Shreya S Bellampalli, Yingshi Ji, Aubin Moutal, Song Cai, E M Kithsiri Wijeratne, Maria A Gandini, Jie Yu, Aude Chefdeville, Angie Dorame, Lindsey A Chew, Cynthia L Madura, Shizhen Luo, Gabriella Molnar, May Khanna, John M Streicher, Gerald W Zamponi, A A Leslie Gunatilaka, Rajesh Khanna

Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1

型神经纤维瘤病猪模型的伤害感受和相关生活质量指标评估

Rajesh Khanna, Aubin Moutal, Katherine A White, Aude Chefdeville, Pedro Negrao de Assis, Song Cai, Vicki J Swier, Shreya S Bellampalli, Marissa D Giunta, Benjamin W Darbro, Dawn E Quelle, Jessica C Sieren, Margaret R Wallace, Christopher S Rogers, David K Meyerholz, Jill M Weimer

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy

针对 CaVα-CaVβ 相互作用可产生具有广泛抗伤害功效的 N 型 CaV2.2 通道拮抗剂

Rajesh Khanna, Jie Yu, Xiaofang Yang, Aubin Moutal, Aude Chefdeville, Vijay Gokhale, Zunaira Shuja, Lindsey A Chew, Shreya S Bellampalli, Shizhen Luo, Liberty François-Moutal, Maria J Serafini, Taehwan Ha, Samantha Perez-Miller, Ki Duk Park, Amol M Patwardhan, John M Streicher, Henry M Colecraft, Ma

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

与抗N-甲基-D-天冬氨酸受体脑炎相关的卵巢畸胎瘤的免疫病理学特征

Chefdeville, Aude; Treilleux, Isabelle; Mayeur, Marie-Eve; Couillault, Coline; Picard, Géraldine; Bost, Chloé; Mokhtari, Karima; Vasiljevic, Alexandre; Meyronet, David; Rogemond, Véronique; Psimaras, Dimitri; Dubois, Bertrand; Honnorat, Jérôme; Desestret, Virginie