Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ
鉴定出一种口服生物利用度高的化合物RP-6685,该化合物可抑制Polθ的DNA聚合酶活性。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.2c00998
Monica Bubenik ,Pavel Mader ,Philippe Mochirian ,Fréderic Vallée ,Jillian Clark ,Jean-François Truchon ,Alexander L Perryman ,Victor Pau ,Igor Kurinov ,Karl E Zahn ,Marie-Eve Leclaire ,Robert Papp ,Marie-Claude Mathieu ,Martine Hamel ,Nicole M Duffy ,Claude Godbout ,Matias Casas-Selves ,Jean-Pierre Falgueyret ,Prasamit S Baruah ,Olivier Nicolas ,Rino Stocco ,Hugo Poirier ,Giovanni Martino ,Alexanne Bonneau Fortin ,Anne Roulston ,Amandine Chefson ,Stéphane Dorich ,Miguel St-Onge ,Purvish Patel ,Charles Pellerin ,Stéphane Ciblat ,Thomas Pinter ,Francis Barabé ,Majida El Bakkouri ,Paranjay Parikh ,Christian Gervais ,Agnel Sfeir ,Yael Mamane ,Stephen J Morris ,W Cameron Black ,Frank Sicheri ,Michel Gallant