Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.
膜型 1 基质金属蛋白酶的激活需要自身抑制前结构域的内部切割，尽管单独使用弗林蛋白酶切割会产生无活性的蛋白酶
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M110.135442
Golubkov Vladislav S, Cieplak Piotr, Chekanov Alexei V, Ratnikov Boris I, Aleshin Alexander E, Golubkova Natalya V, Postnova Tatiana I, Radichev Ilian A, Rozanov Dmitri V, Zhu Wenhong, Motamedchaboki Khatereh, Strongin Alex Y
