日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Optimization of a micro-scale air-liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2

优化用于中等通量SARS-CoV-2药物筛选的人类近端气道上皮微尺度气液界面模型

Sen, Chandani; Rickabaugh, Tammy M; Jeyachandran, Arjit Vijey; Yuen, Constance; Ghannam, Maisam; Durra, Abdo; Aziz, Adam; Castillo, Kristen; Garcia, Gustavo Jr; Purkayastha, Arunima; Han, Brandon; Boulton, Felix W; Chekler, Eugene; Garces, Robert; Wolff, Karen C; Riva, Laura; Kirkpatrick, Melanie G; Gebara-Lamb, Amal; McNamara, Case W; Betz, Ulrich A K; Arumugaswami, Vaithilingaraja; Damoiseaux, Robert; Gomperts, Brigitte N

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

将TLR7激动剂靶向递送至肿瘤微环境可通过激活肿瘤驻留髓系细胞增强肿瘤免疫力

Sega, Emanuela; Kotapati, Srikanth; Poudel, Yam B; Cheng, Qinqin; Sadanala, Keerthi; Schneider, Bridget; Chekler, Eugene P; Rao, Chetana; Gangwar, Sanjeev; Sproul, Tim; Law, Deborah; Broz, Miranda; Strop, Pavel; Yamazoe, Sayumi

Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A

使用磷酸二酯酶 PDE5A 和 PDE9A 抑制剂逆转营养不良小鼠的神经行为社交缺陷

M S Alexander, M J Gasperini, P T Tsai, D E Gibbs, J M Spinazzola, J L Marshall, M J Feyder, M T Pletcher, E L P Chekler, C A Morris, M Sahin, J F Harms, C J Schmidt, R J Kleiman, L M Kunkel

Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin

细胞蛋白质稳态网络的扰动可识别调节 frataxin 前体和中间体水平(而非成熟水平)的途径

Joseph F Nabhan, Renea L Gooch, Eugene L Piatnitski Chekler, Betsy Pierce, Christine E Bulawa

Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.

新型口服微管蛋白聚合抑制剂 IMC-038525 的抗肿瘤活性

Tuma Maria Carolina, Malikzay Asra, Ouyang Xiaohu, Surguladze David, Fleming James, Mitelman Stan, Camara Margarita, Finnerty Bridget, Doody Jacqueline, Chekler Eugene L P, Kussie Paul, Tonra James R