日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of TCE-secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity.

CD3É› 纳米抗体工程化细胞外囊泡驱动体内生成分泌 TCE 的 CAR-T 细胞，用于实体瘤治疗，具有记忆反应和最小免疫原性。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202519440
Huang Shi-Wei, Lin Yu-Chuan, Pan Chih-Ming, Chen Yeh, Shie Ming-You, Chen Cheng-Yu, Kan Kai-Wen, Chen Yi-Wen, Liu Ming-Chao, Wu Chung-Chun, Chiang Yu-Ting, Ho Huai-Ping, Lin Chen-Yu, Lin Pei-Ying, Huang Yu-Han, Rusli Steffany, Mao Wan-Yu, Huang Pei-Wen, Wang Sin-Ting, Tsai Wan-Chen, Chiu Ya-Hsu, Lin Ting-Hsun, Chiang Wan-Ling, Chang Che-Kai, Lai Zi-Lun, Chen Mei-Chih, Chiu Shao-Chih, Cho Der-Yang
细胞生物学
CD3
囊泡
发表日期：2026
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Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury

构建靶向整合素αvβ8的细胞外囊泡，以递送BDNF mRNA促进脊髓损伤后的运动功能恢复

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-026-04222-7
Shie, Ming-You; Chiu, Cheng-Di; Chen, Yeh; Lin, Yen-Hong; Yu, Min-Hua; Chiu, You-Pen; Chiu, Po-Fan; Chen, Cheng-Yu; Chen, Yi-Wen; Chen, Mei-Chih; Cho, Der-Yang
神经科学
脊髓损伤
BDNF
囊泡
细胞生物学
发表日期：2026
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RNase1-driven ALK-activation is an oncogenic driver and therapeutic target in non-small cell lung cancer

RNase1驱动的ALK激活是非小细胞肺癌的致癌驱动因素和治疗靶点。

期刊:Signal Transduction and Targeted Therapy
影响因子:40.8
doi:10.1038/s41392-025-02206-x
Zhengyu Zha # ，Chunxiao Liu # ，Meisi Yan # ，Cong Chen # ，Cheng Yu ，Yaohui Chen ，Chenhao Zhou ，Lu Li ，Yi-Chuan Li ，Hiro Yamaguchi ，Leiguang Ye ，Tong Liu ，Ying-Nai Wang ，Heng-Huan Lee ，Wen-Hao Yang ，Li-Chuan Chan ，Baozhen Ke ，Jennifer L Hsu ，Lieming Ding ，Dong Ji ，Peng Pan ，Yiran Meng ，Yue Pu ，Lunxu Liu ，Mien-Chie Hung
肺癌
细胞生物学
肿瘤
ALK
肿瘤免疫
发表日期：2025
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Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery.

构建靶向 HLA-G 的细胞外囊泡纳米平台，通过精准的癌症药物递送增强癌症治疗效果。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66451-y
Shie Ming-You, Huang Shi-Wei, Chen Yeh, Chen Mei-Chih, Pan Chih-Ming, Chen Cheng-Yu, Lin Yen-Hong, Yu Min-Hua, Kan Kai-Wen, Chiu Shao-Chih, Ho Hui-Chun, Chen Yi-Wen, Cho Der-Yang
细胞生物学
囊泡
发表日期：2025
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Innovative dual-gene delivery platform using miR-124 and PD-1 via umbilical cord mesenchymal stem cells and exosome for glioblastoma therapy

利用脐带间充质干细胞和外泌体递送miR-124和PD-1的创新型双基因递送平台用于胶质母细胞瘤治疗

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-025-03336-4
Yueh, Po-Fu; Chiang, I-Tsang; Weng, Yueh-Shan; Liu, Yu-Chang; Wong, Raymond C B; Chen, Cheng-Yu; Hsu, Justin Bo-Kai; Jeng, Long-Bin; Shyu, Woei-Cherng; Hsu, Fei-Ting
外泌体
发育与干细胞
干细胞
细胞生物学
PD-1
发表日期：2025
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Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson's disease therapy

利用工程化细胞外囊泡介导的姜黄素递送系统，在大脑微环境中调节溶酶体、线粒体和小胶质细胞的重编程，从而治疗帕金森病。

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03911-z
Shie, Ming-You; Chen, Mei-Chih; Chen, Yeh; Huang, Shi-Wei; Lin, Yen-Hong; Yu, Min-Hua; Pan, Chih-Ming; Chen, Cheng-Yu; Chen, Yi-Wen; Hsieh, Ching-Liang; Chiu, Shao-Chih; Kao, Shung-Te; Lin, Jaung-Geng; Cho, Der-Yang
胶质细胞
帕金森
神经科学
线粒体
囊泡
细胞生物学
发表日期：2025
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Lithium-doped calcium silicate scaffolds-activated M2-polarized macrophage-derived miR-145-5p-riched extracellular vesicles to enhance osteoimmunomodulation for accelerating bone regeneration

锂掺杂硅酸钙支架激活M2极化巨噬细胞来源的富含miR-145-5p的细胞外囊泡，从而增强骨免疫调节，加速骨再生

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03679-2
Kuo, Ting-You; Lin, Tsung-Li; Lin, Yen-Hong; Chen, Cheng-Yu; Cho, Der-Yang; Chen, Yi-Wen; Shie, Ming-You
巨噬细胞
细胞生物学
囊泡
巨噬细胞
免疫/内分泌
发表日期：2025
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Osteoimmunomodulation of astragalus-calcium silicate scaffolds-activated M2 macrophage-derived miR-218-rich exosome for enhanced bone regeneration

黄芪-硅酸钙支架激活M2巨噬细胞来源的富含miR-218的外泌体，从而增强骨再生，发挥骨免疫调节作用

期刊:Materials Today Bio
影响因子:10.2
doi:10.1016/j.mtbio.2025.102286
Chen, Cheng-Yu; Lee, Jian-Jr; Lin, Yen-Hong; Kuo, Ting-You; Cho, Der-Yang; Shie, Ming-You
巨噬细胞
外泌体
细胞生物学
巨噬细胞
免疫/内分泌
发表日期：2025
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Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration

锂掺杂硅酸钙水泥调节免疫微环境，促进M2型巨噬细胞极化，从而增强骨再生。

期刊:Journal of Biological Engineering
影响因子:6.5
doi:10.1186/s13036-024-00467-8
Lin, Yen-Hong; Chen, Cheng-Yu; Chen, Kun-Hao; Kuo, Ting-You; Lin, Tsung-Li; Shie, Ming-You
巨噬细胞
巨噬细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Microbiota-gut-brain axis in avian parenting: gut microbiome associates with nest-construction behavior and neural gene expression in a songbird

鸟类育雏中的肠道菌群-肠-脑轴：鸣禽肠道微生物群与筑巢行为和神经基因表达相关

期刊:Animal Microbiome
影响因子:4.4
doi:10.1186/s42523-025-00486-w
Chen, Cheng-Yu; Kuo, Hao-Chih; Fang, Yi-Ting; Lu, Chia-Wei; Chen, Shih-Kuo; Hung, Chih-Ming
微生物学
肠道菌群
神经科学
发表日期：2025
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