Chen Ken相关文献与解析，生知库 | 链接生命科学的每一步

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

空间分析揭示了小鼠肺腺癌前病变在致癌物暴露与否下的分子和免疫演变差异

doi:10.1002/advs.202512597

Zhu, Bo; Aminu, Muhammad; Chen, Pingjun; Li, Jian-Rong; Dong, Chuanpeng; Li, Chenyang; Tian, Yanhua; Lu, Shao-Wei; Chen, Hong; Ma, Chenxi; Hu, Xin; Ye, Jie; Liu, Andrew Y; Huang, Beibei; Rojas, Frank R; Roger, Parra Cuentas Edwin; Shi, Ou; Nilsson, Monique B; Poteete, Alissa; Khan, Khaja B; Lu, Wei; Solis Soto, Luisa M; Fujimoto, Junya; Haymaker, Cara; Wistuba, Ignacio I; Wei, Zhubo; Wang, Linghua; Gibbons, Don L; Chen, Ken; Reuben, Alexandre; Schenkel, Jason M; Heymach, John V; Cheng, Chao; Wu, Jia; Zhang, Jianjun

Agent-based modeling of cellular dynamics in adoptive cell therapy

基于代理的过继细胞疗法中细胞动力学建模

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-026-09653-4

Wang, Yujia; Casarin, Stefano; Daher, May; Mohanty, Vakul; Dede, Merve; Shanley, Mayra; Dondossola, Eleonora; La Posta, Ludovica; Başar, Rafet; Rezvani, Katayoun; Chen, Ken

细胞生物学

发表日期：2026

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Early Postoperative PSA Dynamics and Prognostic Implications After Radical Prostatectomy

根治性前列腺切除术后早期PSA动态变化及其预后意义

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers18050850

Tan, Yukun; Meng, Qing H; Dede, Merve; Huang, Ingold; Song, Hui; Chen, Ken; Zhang, Yu

PSA

发表日期：2026

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Treatment Patterns and Clinical Outcomes in Unresectable Stage III EGFR-Mutated Non-Small Cell Lung Cancer in China

中国不可切除的III期EGFR突变型非小细胞肺癌的治疗模式和临床结果

期刊:Advances in Therapy

影响因子:4

doi:10.1007/s12325-025-03488-x

Lu, Shun; Li, Xingya; Wang, Changchun; Chen, Ken; Liang, Yong; Yin, Zheng; Nasirova, Feruza; Kim, YongJin

Administration practice and adherence of nusinersen in adults with 5q-spinal muscular atrophy in China: an ambispective multicenter study

中国成人5q-脊髓性肌萎缩症患者诺西那生给药实践及依从性：一项前瞻性多中心研究

期刊:BMC Neurology

影响因子:2.2

doi:10.1186/s12883-026-04730-x

Yao, Xiaoli; Dai, Yi; Zhu, Wenhua; Zhao, Yuying; Shang, Huifang; Meng, Qiang; Liu, Yaling; Yu, Liqiang; Hong, Daojun; Chen, Juanjuan; Shen, Lu; Chen, Wanjin; Chen, Ken; Zhang, Li; Mai, Maerhaba; Cui, Liying

Spatial immune hubs defined by conserved activated dendritic cells are remodeled by immunotherapy

由保守的活化树突状细胞定义的空间免疫枢纽可通过免疫疗法进行重塑。

期刊:

影响因子:

doi:10.64898/2026.02.10.703136

Minowa, Tomoyuki; Keshari, Sunita; He, Shan; Saha, Akata; Shavkunov, Alexander S; Pineda, Josué E; Yeo, Yao Yu; Zhu, Bokai; Mohanty, Vakul; Jindal, Sonali; Chen, Ken; Hu, Kenneth H; Wang, Linghua; Nolan, Garry P; Watowich, Stephanie S; Gubin, Matthew M

AI-powered Immune Cell Knowledge Graph (ICKG) with granular immune contexts enables immune program interpretation

基于人工智能的免疫细胞知识图谱（ICKG）结合精细的免疫背景信息，能够解读免疫程序。

期刊:

影响因子:

doi:10.1038/s44387-025-00060-4

He, Shan; Tan, Yukun; Ye, Qing; M Gubin, Matthew; Dede, Merve; Rafei, Hind; Peng, Weiyi; Rezvani, Katayoun; Mohanty, Vakul; Chen, Ken

TNFAIP8/TIPE2 inactivation modulates extracellular matrix organization gene expression and preserves the intervertebral disc structure in mice

TNFAIP8/TIPE2失活调节细胞外基质组织基因表达，并维持小鼠椎间盘结构。

期刊:Genes and Diseases

影响因子:

doi:10.1016/j.gendis.2025.101835

Tian, Zuozhen; Chen, Ken; Shofer, Frances S; Chenna, Srish S; Sandroni, Daniel Z; Qin, Ling; Zhang, Yejia

Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade.

效应调节性 T 细胞的耗竭与诱导双重免疫检查点阻断的主要反应相关

期刊:Cancer Discovery

影响因子:33.3

doi:10.1158/2159-8290.CD-24-1390

Jiang Xianli, Rudqvist Nils-Petter, Jiang Bo, Ye Shengbin, He Shan, Liang Qingnan, Dou Jinzhuang, Williams Michelle D, Dunn Joe Dan, Johnson Jason M, Akagi Keiko, Xiao Weihong, Liang Shaoheng, Elayavalli Satvik, Sun Baohua, Parra Edwin R, Ferrarotto Renata, Garden Adam S, Fuller Clifton David, Reddy Jay, Gross Neil D, Lango Miriam N, Leung Cheuk Hong, Liu Suyu, Liu Diane D, Li Meng, Lee J Jack, Curran Michael A, Phan Jack, Chen Ken, Gillison Maura L

细胞生物学

发表日期：2025

文献求助收藏

Aging drives a program of DNA methylation decay in plant organs

衰老会引发植物器官中DNA甲基化水平的下降。

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

空间分析揭示了小鼠肺腺癌前病变在致癌物暴露与否下的分子和免疫演变差异

Agent-based modeling of cellular dynamics in adoptive cell therapy

基于代理的过继细胞疗法中细胞动力学建模

Early Postoperative PSA Dynamics and Prognostic Implications After Radical Prostatectomy

根治性前列腺切除术后早期PSA动态变化及其预后意义

Treatment Patterns and Clinical Outcomes in Unresectable Stage III EGFR-Mutated Non-Small Cell Lung Cancer in China

中国不可切除的III期EGFR突变型非小细胞肺癌的治疗模式和临床结果

Administration practice and adherence of nusinersen in adults with 5q-spinal muscular atrophy in China: an ambispective multicenter study

中国成人5q-脊髓性肌萎缩症患者诺西那生给药实践及依从性：一项前瞻性多中心研究

Spatial immune hubs defined by conserved activated dendritic cells are remodeled by immunotherapy

由保守的活化树突状细胞定义的空间免疫枢纽可通过免疫疗法进行重塑。

AI-powered Immune Cell Knowledge Graph (ICKG) with granular immune contexts enables immune program interpretation

基于人工智能的免疫细胞知识图谱（ICKG）结合精细的免疫背景信息，能够解读免疫程序。

TNFAIP8/TIPE2 inactivation modulates extracellular matrix organization gene expression and preserves the intervertebral disc structure in mice

TNFAIP8/TIPE2失活调节细胞外基质组织基因表达，并维持小鼠椎间盘结构。

Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade.

效应调节性 T 细胞的耗竭与诱导双重免疫检查点阻断的主要反应相关