日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and functional evaluation of a synthetic lamina cover that replaces lost autologous spinal bone after laminectomy, in a sheep and human study

在一项绵羊和人体研究中,对用于替代椎板切除术后丢失的自体脊柱骨的合成椎板覆盖物的安全性和功能性进行了评估。

Chen, Cheng-Kuang; Chiang, Ming-Fu; Yao, Yu-Cheng; Chang, Ming-Chau; Schönthal, Axel H; Chen, Thomas C

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV-induced skin damage.

NEO400(紫苏醇与亚油酸的结合物)在紫外线诱导皮肤损伤小鼠模型中的治疗效果

Swenson Stephen, Silva-Hirschberg Catalina, Freeland Liliana, Chen Kristen L, Marín-Ramos Nagore I, Schönthal Axel H, Chen Thomas C

Potent Therapeutic Activity of NEO212 in Preclinical Models of Human and Canine Leukaemia and Lymphoma

NEO212在人类和犬白血病和淋巴瘤的临床前模型中表现出强大的治疗活性

Chen, Thomas C; Swenson, Steve; Thein, Thu Zan; Minea, Radu O; Schönthal, Axel H

Patient with recurrent grade 4 astrocytoma responding favorably to intranasal delivery of NEO100, highly pure perillyl alcohol: illustrative case

一例复发性4级星形细胞瘤患者经鼻内给药NEO100(高纯度紫苏醇)后疗效显著:病例报告

Schönthal, Axel H; Swenson, Stephen; Senecal, Frank M; Mittenzwei, Rhonda; Go, John L; Chen, Thomas C

Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model

在绵羊模型中,通过植入式智能泵实现外部控制的节律性脑部药物输送的应用及安全性

Chen, Thomas C; Wu, Winston H; Chang, Ki-Eun; Schönthal, Axel H; Gang, Eli S; Indravudh, Vic; Lobl, Thomas; Adell, Frank; Shachar, Yehoshua

Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism

对人类神经元中自闭症相关神经连接蛋白 3 R451C 突变的分析揭示了一种获得功能的突触机制

Le Wang #, Vincent R Mirabella #, Rujia Dai, Xiao Su, Ranjie Xu, Azadeh Jadali, Matteo Bernabucci, Ishnoor Singh, Yu Chen, Jianghua Tian, Peng Jiang, Kevin Y Kwan, ChangHui Pak, Chunyu Liu, Davide Comoletti, Ronald P Hart, Chao Chen, Thomas C Südhof, Zhiping P Pang

MicroRNA-133b Dysregulation in a Mouse Model of Cervical Contusion Injury

小鼠颈椎挫伤模型中microRNA-133b表达失调

Yu, James Young Ho; Chen, Thomas C; Danilov, Camelia A

NEO212, temozolomide conjugated to NEO100, exerts superior therapeutic activity over temozolomide in preclinical chemoradiation models of glioblastoma

NEO212(替莫唑胺与NEO100的偶联物)在胶质母细胞瘤的临床前放化疗模型中,其治疗活性优于替莫唑胺。

Minea, Radu O; Thein, Thu Zan; Yang, Zhuoyue; Campan, Mihaela; Ward, Pamela M; Schönthal, Axel H; Chen, Thomas C

Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury

脊髓损伤后非CpG甲基化水平降低是一个潜在的表观遗传学靶点

Wu, Zhourui; Li, Chen; Zhu, Ran; Cao, Yiqiu; Chen, Thomas C; Cheng, Liming

Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies

在脑部局部恶性肿瘤小鼠模型中,动脉内注射NEO100可促进检查点抑制治疗性抗体进入大脑。

Wang, Weijun; He, Haiping; Zeng, Shan; Cho, Hee-Yeon; Minea, Radu O; Swenson, Steven D; Zheng, Long; Epstein, Alan L; Stathopoulos, Apostolos; Chen, Ligang; Schönthal, Axel H; Chen, Thomas C