日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Artificial Intelligence to Guide Repurposing of Drugs

人工智能指导药物再利用

Fu, Zhimin; Yang, Yuxin; Chung, Mina K; Cheng, Feixiong

Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery

结合来自不同人群的 xQTL 和全基因组关联研究,可以提高药物靶向基因的发现效率。

Lorincz-Comi, Noah; Song, Wenqiang; Chen, Xin; Paz, Isabela Rivera; Hou, Yuan; Zhou, Yadi; Xu, Jielin; Martin, William; Barnard, John; Pieper, Andrew A; Haines, Jonathan L; Chung, Mina K; Cheng, Feixiong

The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis

线粒体守护者α-香树脂醇通过调节DLK-SARM1-ULK1轴减轻阿尔茨海默病病理

Cao, Shu-Qin; Jiménez-Loygorri, Juan Ignacio; Qiu, Yunguang; Kang, You Jung; Do, Khanh Van; Smith, Annabel E; Huang, Junjie; Pan, Jun-Ping; Mao, Lipeng; Li, Ang; Yang, Hangge; Aman, Yahyah; Lagartos, Maria Jose Donate; Lautrup, Sofie Hindkjær; Chen, Anbin; Liang, Kristina Xiao; Zhang, Hailong; Yi, Juan; Jin, Xurui; Cheung, Tin Cho; Apokotou, Olympia; Papastefanaki, Florentia; Matsas, Rebecca; McEwan, William A; Cheng, Feixiong; Cho, Hansang; Chen, Guobing; Su, Huanxing; Palikaras, Konstantinos; Luo, Oscar Junhong; Zhao, Qian Hua; Ding, Ding; van Duijn, Cornelia; Tavernarakis, Nektarios; Boya, Patricia; Tencomnao, Tewin; Fang, Evandro F

A Quantum Framework for Protein Binding-Site Structure Prediction on Utility-Level Quantum Processors

基于实用级量子处理器的蛋白质结合位点结构预测量子框架

Zhang, Yuqi; Yang, Yuxin; Martin, William; Lin, Kingsten; Wang, Zixu; Lu, Cheng-Chang; Jiang, Weiwen; Nussinov, Ruth; Loscalzo, Joseph; Guan, Qiang; Cheng, Feixiong

Multi-View Biomedical Foundation Models for Molecule-Target and Property Prediction

用于分子靶点和性质预测的多视角生物医学基础模型

Suryanarayanan, Parthasarathy; Qiu, Yunguang; Sethi, Shreyans; Mahajan, Diwakar; Li, Hongyang; Yang, Yuxin; Eyigoz, Elif; Guzmán-Sáenz, Aldo; Platt, Daniel E; Rumbell, Timothy H; Ng, Kenney; Dey, Sanjoy; Burch, Myson; Kwon, Bum Chul; Meyer, Pablo; Cheng, Feixiong; Hu, Jianying; Morrone, Joseph A

Network-based prediction and real-world patient data observation identify doxycycline as a repurposable drug in Alzheimer's disease

基于网络预测和真实世界患者数据观察的研究表明,多西环素可作为阿尔茨海默病的一种可再利用药物。

Bykova, Marina; Karavani, Ehud; Danziger, Michael; Tonegawa-Kuji, Reina; Martin, William; Sha, Zhendong; Pieper, Andrew A; Rosen-Zvi, Michal; Cheng, Feixiong

Critical evaluation of real-world evidence of repurposable medicines in the Alzheimer's disease drug development pipeline using a target trial emulation

利用目标试验模拟对阿尔茨海默病药物研发管线中可再利用药物的真实世界证据进行批判性评估

Tonegawa-Kuji, Reina; Karavani, Ehud; Danziger, Michael; Zhang, Pengyue; Hou, Yuan; Zhou, Yadi; Bykova, Marina; Pieper, Andrew A; Rosen-Zvi, Michal; Cummings, Jeffrey; Cheng, Feixiong

Biomarkers in Alzheimer's disease clinical trials: 2025

阿尔茨海默病临床试验中的生物标志物:2025

Osse, Amanda M Leisgang; Zhou, Yadi; Kinney, Jefferson W; Hooyman, Andrew; Sengupta, Ayan; Fonseca, Jorge; Burstein, Aaron H; Owen, Meriel; Nisenbaum, Laura; Fillit, Howard M; Cheng, Feixiong; Cummings, Jeffrey L

Cell type-specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease

细胞类型特异性基因调控图谱优先考虑阿尔茨海默病中的药物靶点和可再利用药物

Ren, Yunxiao; Hu, Ming; Li, Yang E; Pieper, Andrew A; Cummings, Jeffrey; Cheng, Feixiong

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease

人类兴奋性神经元相互作用组图谱揭示了阿尔茨海默病的新风险基因和通路

Wei, Xiaomu; Munechika, Katie; Sun, Yu; Wan, Yuansong; Xia, Tianyu; Hou, Yuan; Song, Wenqiang; Yugandhar, Kumar; Wang, Yiwen; Lee, Se-In; Sha, Zhengdong; Zhou, Yadi; Feng, Weixi; Zhu, Jingjie; Tang, Yuliang; Luo, Wenjie; Cheng, Feixiong; Gan, Li; Yu, Haiyuan