Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC.
小分子化合物 PEITC 可直接抑制 TXNIP-NLRP3-GSDMD 通路，从而减少结肠细胞焦亡，缓解小鼠溃疡性结肠炎
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01549-z
Wang Jie, Zhang Cui, Qin Jia, An Ning, Bai Mei, Du Rong-Hui, Shen Yan, Wu Xu-Dong, Cheng Jing-Cai, Wu Xue-Feng, Xu Qiang
