Costunolide normalizes neuroinflammation and improves neurogenesis deficits in a mouse model of depression through inhibiting microglial Akt/mTOR/NF-κB pathway.
Costunolide 通过抑制小胶质细胞 Akt/mTOR/NF-κB 通路，使抑郁症小鼠模型中的神经炎症正常化并改善神经发生缺陷
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01506-w
Zhang Shao-Qi, Deng Qiao, Tian Cheng, Zhao Huan-Huan, Yang Li-Ying, Cheng Xin-Wei, Wang Guo-Ping, Liu Dong
神经科学
细胞生物学
抑郁症
神经炎症
mTOR
Mouse
炎症
