日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML

在Ptpn11相关的幼年型粒单核细胞白血病(JMML)中,白血病起始干细胞劫持先天免疫机制以获得选择性优势和免疫逃逸。

Hong Zheng ,Peng Zhao ,Zhenya Tan ,Wen-Mei Yu ,Juwita Werner ,Elliot Stieglitz ,Christopher C Porter ,Shanmuganathan Chandrakasan ,Daniel S Wechsler ,Simon Mendez-Ferrer ,Cheng-Kui Qu

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis

SHP2作为一种原始的表观遗传酶,能够清除组蛋白H3 pTyr-54,从而调节雄激素受体的稳态。

Surbhi Chouhan #,Dhivya Sridaran #,Cody Weimholt,Jingqin Luo,Tiandao Li,Myles C Hodgson,Luana N Santos,Samantha Le Sommer,Bin Fang,John M Koomen,Markus Seeliger,Cheng-Kui Qu,Armelle Yart,Maria I Kontaridis,Kiran Mahajan,Nupam P Mahajan

Prototypical innate immune mechanism hijacked by leukemia-initiating mutant stem cells for selective advantage and immune evasion in Ptpn11-associated juvenile myelomonocytic leukemia

原型先天免疫机制被白血病起始突变干细胞劫持,在 Ptpn11 相关青少年粒单核细胞白血病中实现选择性优势和免疫逃避

Hong Zheng, Peng Zhao, Zhenya Tan, Wen-Mei Yu, Juwita Werner, Elliot Stieglitz, Chris Porter, Shanmuganathan Chandrakasan, Daniel Wechsler, Simon Mendez-Ferrer, Cheng-Kui Qu

Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity

线粒体代谢灵活性对 CD8+ T 细胞抗肿瘤免疫至关重要

Chao Chen, Hong Zheng, Edwin M Horwitz, Satomi Ando, Koichi Araki, Peng Zhao, Zhiguo Li, Mandy L Ford, Rafi Ahmed, Cheng-Kui Qu

AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling

AMPK 激活剂处理的人类心脏球可促进成熟并实现病理建模

Dong Li, Lawrence C Armand, Fangxu Sun, Hyun Hwang, David Wolfson, Antonio Rampoldi, Rui Liu, Parvin Forghani, Xin Hu, Wen-Mei Yu, Cheng-Kui Qu, Dean P Jones, Ronghu Wu, Hee Cheol Cho, Joshua T Maxwell, Chunhui Xu

Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

Ptpmt1 的缺失会限制线粒体对碳水化合物的利用,并导致组织特异性敲除小鼠的肌肉萎缩和心力衰竭

Hong Zheng #, Qianjin Li #, Shanhu Li #, Zhiguo Li, Marco Brotto, Daiana Weiss, Domenick Prosdocimo, Chunhui Xu, Ashruth Reddy, Michelle Puchowicz, Xinyang Zhao, M Neale Weitzmann, Mukesh K Jain, Cheng-Kui Qu

Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

细胞信号汇聚于 NOX2-SHP-2 轴,诱导癌细胞发生还原羧化

Rukang Zhang, Dong Chen, Hao Fan, Rong Wu, Jiayi Tu, Freya Q Zhang, Mei Wang, Hong Zheng, Cheng-Kui Qu, Shannon E Elf, Brandon Faubert, Yu-Ying He, Marc B Bissonnette, Xue Gao, Ralph J DeBerardinis, Jing Chen

Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis

细胞外精氨酸是必需的,但精氨酸转运蛋白 CAT3 (Slc7a3) 对于小鼠正常和恶性造血来说是可有可无的

Yuhan Yan #, Chao Chen #, Zhiguo Li, Jing Zhang, Narin Park, Cheng-Kui Qu

Methylation of dual-specificity phosphatase 4 controls cell differentiation

双特异性磷酸酶4的甲基化调控细胞分化

Hairui Su ,Ming Jiang ,Chamara Senevirathne ,Srinivas Aluri ,Tuo Zhang ,Han Guo ,Juliana Xavier-Ferrucio ,Shuiling Jin ,Ngoc-Tung Tran ,Szu-Mam Liu ,Chiao-Wang Sun ,Yongxia Zhu ,Qing Zhao ,Yuling Chen ,LouAnn Cable ,Yudao Shen ,Jing Liu ,Cheng-Kui Qu ,Xiaosi Han ,Christopher A Klug ,Ravi Bhatia ,Yabing Chen ,Stephen D Nimer ,Y George Zheng ,Camelia Iancu-Rubin ,Jian Jin ,Haiteng Deng ,Diane S Krause ,Jenny Xiang ,Amit Verma ,Minkui Luo ,Xinyang Zhao

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics

Ptpn21 控制造血干细胞稳态和生物力学

Fang Ni ,Wen-Mei Yu ,Xinyi Wang ,Meredith E Fay ,Katherine M Young ,Yongzhi Qiu ,Wilbur A Lam ,Todd A Sulchek ,Tao Cheng ,David T Scadden ,Cheng-Kui Qu