Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation
胰腺癌细胞在隔离压力下上调 LPAR4,以促进富含 ECM 的微环境并支持肿瘤发生
期刊:Nature Cell Biology
影响因子:17.3
doi:10.1038/s41556-022-01055-y
Chengsheng Wu, Taha Rakhshandehroo, Hiromi I Wettersten, Alejandro Campos, Tami von Schalscha, Shashi Jain, Ziqi Yu, Jiali Tan, Evangeline Mose, Betzaira G Childers, Andrew M Lowy, Sara M Weis, David A Cheresh
代谢
信号转导
肿瘤
胰腺癌
肿瘤细胞
Adhesion/ECM