日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling

靶向口服肽类药物Icotrokinra的转化药代动力学研究,该药物可选择性阻断白细胞介素-23受体并抑制信号传导

Knight, Beverly; Tammara, Brinda; Modi, Nishit B; Dallas, Shannon; Mardirosian, Saro; Wang, Jianyao; Laenen, Aline; Leclercq, Laurent; DiLoreto, Karen; Adriaenssen, Lieve; Moss, Darren; Polidori, David; Chaudhuri, Siladitya Ray; Park, Seonghee; Sensenhauser, Carlo; Ndifor, Anthony; Sukumaran, Siddharth; Baguet, Tristan; Shi, Yifan; Patel, Shefali; Geist, Brian; Fourie, Anne; Patch, Raymond; Sun, Chengzao; Barros, Stephanie A; Somani, Sandeep; Monshouwer, Mario

JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans

JNJ-77242113 是一种针对 IL-23 受体的高效选择性肽,在大鼠和人类口服后可产生强大的 IL-23 通路抑制作用

Anne M Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J Allen, Raymond J Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A Rodriguez, Xiaohua Xue, Arun Kannan, T

Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids

具有双重作用机制的肽杂合物可改善啮齿动物的血糖控制并降低体重

Trevaskis, James L; Mack, Christine M; Sun, Chengzao; Soares, Christopher J; D'Souza, Lawrence J; Levy, Odile E; Lewis, Diane Y; Jodka, Carolyn M; Tatarkiewicz, Krystyna; Gedulin, Bronislava; Gupta, Swati; Wittmer, Carrie; Hanley, Michael; Forood, Bruce; Parkes, David G; Ghosh, Soumitra S