日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Derivation of AZD5335, a Novel FRα-Targeted TOP1i-Loaded ADC, for the Treatment of FRα-Expressing Cancers

AZD5335 的衍生化,一种新型的 FRα 靶向 TOP1i 负载抗体偶联药物 (ADC),用于治疗表达 FRα 的癌症

Zoeller, Jason J; Tammali, Ravinder; Dodd, Roger B; Patel, Neki V; Andoni, Alma; Bisha, Ina; Cronin, Shane; De Almeida, Ana; Lee, Nancy; Meekin, John H 3rd; Tilmont, Isabella; Gasper, Diana; Lan, Lingyun; Cox, Megan; Thomas, Tima; Ward, Christopher; Chesebrough, Jon; Anderton, Judith; Neal, Frances; Zenonos, Zenon; Shandilya, Harini; Chooi, K Phin; Pugh, Kathryn; Saleh, Ali; Wang, Jixin; Mitchell, Pat; Naseer, Humaira; Beaumont, Kevin; Hood, John; Myers, Claire; Christ, Simon; Dino, Iris; Guza, Xhenifer; Falck, Tillmann; Lehmann, Michael; Sargeant, Rebecca; Godfrey, Lisa; Recolin, Benedicte; Brier, Tim; Turner, Simon; Rosfjord, Edward; Fraenkel, Paula G; Cosulich, Sabina; Gymnopoulos, Marco; Hurt, Elaine; Sapra, Puja

Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial

度伐利尤单抗联合叶酸受体α疫苗TPIV200治疗晚期卵巢癌患者的安全性、免疫原性和临床疗效:一项II期试验

Zamarin, Dmitriy; Walderich, Sven; Holland, Aliya; Zhou, Qin; Iasonos, Alexia E; Torrisi, Jean M; Merghoub, Taha; Chesebrough, Lewis F; Mcdonnell, Autumn S; Gallagher, Jacqueline M; Li, Yanyun; Hollmann, Travis J; Grisham, Rachel N; Erskine, Courtney L; Block, Mathew S; Knutson, Keith L; O'Cearbhaill, Roisin E; Aghajanian, Carol; Konner, Jason A

Antibody-Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

含有吡咯并苯二氮卓类或微管蛋白酶有效载荷的抗体-药物偶联物具有免疫调节作用,并与多种免疫疗法产生协同作用

Jonathan Rios-Doria, Jay Harper, Raymond Rothstein, Leslie Wetzel, Jon Chesebrough, Allison Marrero, Cui Chen, Patrick Strout, Kathy Mulgrew, Kelly McGlinchey, Ryan Fleming, Binyam Bezabeh, John Meekin, David Stewart, Maureen Kennedy, Philip Martin, Andrew Buchanan, Nazzareno Dimasi, Emil Michelotti

Evaluating the performance of selection scans to detect selective sweeps in domestic dogs

评估选择扫描检测家犬选择性清除的性能

Schlamp, Florencia; van der Made, Julian; Stambler, Rebecca; Chesebrough, Lewis; Boyko, Adam R; Messer, Philipp W

Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models

多柔比星酯与癌症免疫疗法协同作用,增强同源小鼠模型中的抗肿瘤反应。

Rios-Doria, Jonathan; Durham, Nicholas; Wetzel, Leslie; Rothstein, Raymond; Chesebrough, Jon; Holoweckyj, Nicholas; Zhao, Wei; Leow, Ching Ching; Hollingsworth, Robert

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

ADAM17 单克隆抗体通过抑制 EGFR 和非 EGFR 介导的通路来抑制肿瘤生长

Jonathan Rios-Doria, Darrin Sabol, Jon Chesebrough, Dave Stewart, Linda Xu, Ravinder Tammali, Li Cheng, Qun Du, Kevin Schifferli, Ray Rothstein, Ching Ching Leow, Jenny Heidbrink-Thompson, Xiaofang Jin, Changshou Gao, Jay Friedman, Brandy Wilkinson, Melissa Damschroder, Andrew J Pierce, Robert E Hol

Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth

双重 IGF-I/II 中和抗体 MEDI-573 可有效抑制 IGF 信号传导和肿瘤生长

Jin Gao, Jon W Chesebrough, Susan A Cartlidge, Sally-Ann Ricketts, Leonard Incognito, Margaret Veldman-Jones, David C Blakey, Mohammad Tabrizi, Bahija Jallal, Pamela A Trail, Steven Coats, Klaus Bosslet, Yong S Chang