日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression

SUCLG1 限制 POLRMT 琥珀酰化以增强线粒体的生物合成和白血病进展

Weiwei Yan #, Chengmei Xie #, Sijun Sun #, Quan Zheng #, Jingyi Wang, Zihao Wang, Cheuk-Him Man, Haiyan Wang, Yunfan Yang, Tianshi Wang, Leilei Shi, Shengjie Zhang, Chen Huang, Shuangnian Xu, Yi-Ping Wang

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

质子输出使细胞内 pH 值碱化,并重新编程碳代谢以驱动正常和恶性细胞生长

Cheuk Him Man, Francois E Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P Lin, Anskar Y H Leung, David T Scadden

Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication

激酶激活急性髓系白血病中质子分配的调节及其治疗意义

Cheuk-Him Man #, Xiaoyuan Zeng #, Wing Lam #, Timothy C C Ng, Tsz-Ho Kwok, Kenny C C Dang, Thomas W Y Leung, Nelson K L Ng, Stephen S Y Lam, Chae-Yin Cher, Anskar Y H Leung

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies

小鼠急性髓系白血病体内全基因组 CRISPR 筛选揭示微环境依赖性

Francois E Mercier, Jiantao Shi, David B Sykes, Toshihiko Oki, Maja Jankovic, Cheuk Him Man, Youmna S Kfoury, Elizabeth Miller, Shutao He, Alexander Zhu, Radovan Vasic, John Doench, Alexandre Orthwein, Franziska Michor, David T Scadden

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis

苹果酸酶 2 将克雷布斯循环中间体富马酸与线粒体的生物合成联系起来

Yi-Ping Wang, Azeem Sharda, Shuang-Nian Xu, Nick van Gastel, Cheuk Him Man, Una Choi, Wei Zhong Leong, Xi Li, David T Scadden

Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia

卵泡抑素是 FLT3/ITD 急性髓系白血病的新型治疗靶点和生物标志物

Bai-Liang He #, Ning Yang #, Cheuk Him Man, Nelson Ka-Lam Ng, Chae-Yin Cher, Ho-Ching Leung, Leo Lai-Hok Kan, Bowie Yik-Ling Cheng, Stephen Sze-Yuen Lam, Michelle Lu-Lu Wang, Chun-Xiao Zhang, Hin Kwok, Grace Cheng, Rakesh Sharma, Alvin Chun-Hang Ma, Chi Wai Eric So, Yok-Lam Kwong, Anskar Yu-Hung Leu