日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

靶向 BCL-XL 的 BH3 模拟物对 RB1 缺失和复制压力的实体瘤有效

Varkaris Andreas, Wang Keshan, Nouri Mannan, Kozlova Nina, Schmidt Daniel R, Stavridi Anastasia, Arai Seiji, Ambrosio Nicholas, Poluben Larysa, Jimenez-Vacas Juan M, Westaby Daniel, Carmichael Juliet, Xie Fang, Figueiredo Ines, Buroni Lorenzo, Neeb Antje, Gurel Bora, Chevalier Nicholas, Brown Lisha, Voznesensky Olga, Chen Shao-Yong, Russo Joshua W, Yuan Xin, Juric Dejan, Beltran Himisha, De Bono Johann S, Vander Heiden Matthew G, Einstein David J, Muranen Taru, Corey Eva, Sharp Adam, Balk Steven P

A Rare Presentation of Aggressive Renal Cell Carcinoma and the Utility of Early Molecular Testing in Rapidly Progressing Malignancies: A Case Report

罕见侵袭性肾细胞癌的临床表现及早期分子检测在快速进展性恶性肿瘤中的应用:病例报告

McLoughlin, Daniel E; Chevalier, Nicholas; Choy, Edwin; Cote, Gregory M; Gao, Xin; Juric, Dejan; Reynolds, Kerry L