日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

神经退行性疾病单细胞转录组图谱的比较分析

Shwab, E Keats; Man, Zhaohui; Gingerich, Daniel C; Gamache, Julia; Garrett, Melanie E; Serrano, Geidy E; Beach, Thomas G; Crawford, Gregory E; Ashley-Koch, Allison E; Chiba-Falek, Ornit

Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences

利用多组学方法阐明阿尔茨海默病异质性机制:神经精神症状、共病及性别差异

Shwab, E Keats; Pathak, Gita A; Harvey, Joshua; Belloy, Michael E; Fischer, Corinne E; Lutz, Michael W; Scholz, Sonja W; Cook, Noah; Reid, Danielle M; Chen, Jingchun; Guan, Dylan X; Oliveira, Fabricio; Sinclair, Lindsey I; Imo, Uzochukwu; Creese, Byron; Chiba-Falek, Ornit

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

阿尔茨海默病中小胶质细胞易发生衰老和胆固醇失调

Li, Boyang; Wang, Shaowei; Kerman, Bilal; Hugo, Cristelle; Shwab, E Keats; Shu, Chang; Chiba-Falek, Ornit; Arvanitakis, Zoe; N Yassine, Hussein

Trends and challenges of AAV-delivered gene editing therapeutics for CNS disorders: Implications for neurodegenerative disease

AAV递送基因编辑疗法治疗中枢神经系统疾病的趋势与挑战:对神经退行性疾病的启示

Kantor, Boris; O'Donovan, Bernadette; Chiba-Falek, Ornit

APOE-Targeted Therapeutics for Alzheimer's Disease

针对阿尔茨海默病的APOE靶向疗法

Yassine, Hussein N; Hugo, Cristelle; O'Donovan, Bernadette; Stephens, Isaiah O; Johnson, Lance A; Cole, Gregory; Tcw, Julia; Johansson, Jan; Kisler, Kassandra; Chiba-Falek, Ornit

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

单细胞转录组学揭示了易聚集α-突触核蛋白亚型在突触核蛋白病中的富集

Shwab, E Keats; Pierson, Webb; Gingerich, Daniel C; Man, Zhaohui; Margalit, Sapir; Yona, Dean; Sivan, Asaf; Gamache, Julia; Serrano, Geidy E; Beach, Thomas G; Ebenstein, Yuval; Beck, Roy; Chiba-Falek, Ornit

SNCA -targeted epigenome therapy for Parkinson's disease alleviates pathological and behavioral perturbations in a mouse model.

针对帕金森病的 SNCA 靶向表观基因组疗法可减轻小鼠模型中的病理和行为紊乱

O'Donovan Bernadette, Rittiner Joseph, Upadhya Suraj, Hodgson Dellila, Kantor Boris, Chiba-Falek Ornit

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

APOE基因与痴呆症研究进展:2023年AAIC进展:APOE会议亮点

Kloske, Courtney M; Belloy, Michael E; Blue, Elizabeth E; Bowman, Gregory R; Carrillo, Maria C; Chen, Xiaoying; Chiba-Falek, Ornit; Davis, Albert A; Paolo, Gilbert Di; Garretti, Francesca; Gate, David; Golden, Lesley R; Heinecke, Jay W; Herz, Joachim; Huang, Yadong; Iadecola, Costantino; Johnson, Lance A; Kanekiyo, Takahisa; Karch, Celeste M; Khvorova, Anastasia; Koppes-den Hertog, Sascha J; Lamb, Bruce T; Lawler, Paige E; Guen, Yann Le; Litvinchuk, Alexandra; Liu, Chia-Chen; Mahinrad, Simin; Marcora, Edoardo; Marino, Claudia; Michaelson, Danny M; Miller, Justin J; Morganti, Josh M; Narayan, Priyanka S; Naslavsky, Michel S; Oosthoek, Marlies; Ramachandran, Kapil V; Ramakrishnan, Abhirami; Raulin, Ana-Caroline; Robert, Aiko; Saleh, Rasha N M; Sexton, Claire; Shah, Nilomi; Shue, Francis; Sible, Isabel J; Soranno, Andrea; Strickland, Michael R; Tcw, Julia; Thierry, Manon; Tsai, Li-Huei; Tuckey, Ryan A; Ulrich, Jason D; van der Kant, Rik; Wang, Na; Wellington, Cheryl L; Weninger, Stacie C; Yassine, Hussein N; Zhao, Na; Bu, Guojun; Goate, Alison M; Holtzman, David M

Single-nucleus multi-omics of Parkinson's disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks

帕金森病单核多组学研究揭示了一种谷氨酸能神经元亚型,该亚型易受转录网络改变导致的基因失调的影响。

Shwab, E Keats; Gingerich, Daniel C; Man, Zhaohui; Gamache, Julia; Garrett, Melanie E; Crawford, Gregory E; Ashley-Koch, Allison E; Serrano, Geidy E; Beach, Thomas G; Lutz, Michael W; Chiba-Falek, Ornit

Peripheral metabolism informs on future cognitive decline and development of Alzheimer’s disease in population at risk

外周代谢可预测高危人群未来认知能力下降和阿尔茨海默病的发展。

McKellar, Mehri S; Keys, Jessica R; Filiatreau, Lindsey M; McGee, Kara S; Kuruc, Joann D; Ferrari, Guido; Margolis, David M; Eron, Joseph J; Hicks, Charles B; Gay, Cynthia L; Kulminski, Alexander M; Feng, Fan; Kulminskaya, Irina; Nazarian, Alireza; Loiko, Elena; Loika, Yury; Arnold, Matthias; Mohanty, Ipsita; Caraballo‐Rodriguez, Andres Mauricio; Zemlin, Jasmine; Labus, Jennifer S; Dorrestein, Pieter; Kaddurah‐Daouk, Rima F; Karlawish, Jason; Harkins, Kristin; Pal, Subhamoy; Welsh‐Bohmer, Kathleen A; Roberts, J Scott; Gregoire, Allyson; Reader, Jonathan M; Bakulski, Kelly M; Green, Robert C; Borkowski, Kamil; Liang, Nuanyi; Arnold, Matthias; Bu, Guojun; Kaddurah‐Daouk, Rima; Zhao, Na; Kanekiyo, Takahisa; Schoemaker, Dorothee; Atkins, Alexandra; Abraham, Chelsea; Welch, Matthew; Plassman, Brenda L; Sickel, Nancy; Madsen, Corrine; Klein, Hans; DiGregorio, Danielle T; Welsh‐Bohmer, Kathleen A; Keefe, Richard SE; Slayton, Matthew A; McAllister, Margaret L; Rothrock, Jane; Belhadj, Sarrah; Gillette, Kirsten D; Hovhannisyan, Mariam; Cabeza, Roberto; Davis, Simon W; Yashin, Anatoliy I; Wu, Deqing; Arbeev, Konstantin; Duan, Hongzhe; Holmes, Rachel; Bagley, Olivia; Ukraintseva, Svetlana; Kaddurah‐Daouk, Rima; Lutz, Michael W; Man, Zhaohui; Chiba‐Falek, Ornit; Logue, Mark W; Labadorf, Adam Thomas; O'Neill, Nicholas K; Dickson, Dennis W; Flanagan, Margaret E; Franklin, Erin E; Frosch, Matt P; Gearing, Marla; Jin, Lee‐Way; Kofler, Julia; Lee, Eddie B; Mayeux, Richard; McKee, Ann C; Miller, Carol A; Murray, Melissa E; Nelson, Peter T; Perrin, Richard J; Schneider, Julie A; Stein, Thor D; Teich, Andrew F; Troncoso, Juan C; Wang, Shih‐Hsiu Jerry; Mez, Jesse; Farrer, Lindsay A; Liang, Nuanyi; Nho, Kwangsik; Newman, John W; Arnold, Matthias; Huynh, Kevin; Meikle, Peter J; Borkowski, Kamil; Kaddurah‐Daouk, Rima