日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bheka Thina ("Look At Us"): The Emergence of an Integrated Drug Discovery Ecosystem in South Africa

Bheka Thina(“看看我们”):南非综合药物发现生态系统的兴起

Woodland, John G; Veale, Clinton G L; Chibale, Kelly

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action

一种新型口服生物利用度高的苯甘氨酸-苯并硼氧杂环化合物,具有抗疟活性和潜在的新型作用机制

Morake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; da Rocha, Shanté; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C S; Wittlin, Sergio; Llinás, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S; Chibale, Kelly

Repositioning a Human Kinase Platelet-Derived Growth Factor Receptor Alpha Type II Inhibitor for Malaria and Inhibition of Hemozoin Formation

将人激酶血小板衍生生长因子受体α II型抑制剂重新定位用于疟疾和抑制血红素晶体形成

Mmonwa, Mmakwena M; Audu, Oluwatosin; Maepa, Keletso; Dziwornu, Godwin A; Govender, Preshen; Tshaka, Liso; Burrows, James; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Wicht, Kathryn J; Coulson, Lauren B; Chibale, Kelly

Small Molecule Kinase Inhibitors with In Vitro β-Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning

利用机器学习鉴定出具有体外β-血红素形成活性和恶性疟原虫蛋白激酶G抑制活性的小分子激酶抑制剂

Thibaud, Jessica L; Salomane, Nicolaas; Harries, Sarah; Wicht, Kathryn J; Coulson, Lauren B; Kuter, David; Chibale, Kelly; de Villiers, Katherine A

Structure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits

基于结构和配体的新型 3-胰凝乳蛋白酶样蛋白酶非肽模拟物的发现

Silva-Mendonça, Sabrina; Seanego, Donald; Jurisch, Christopher; Mottin, Melina; Nader Motta, Flávia; S A Rodrigues, Beatriz; S M Junior, Gilberto; Dos Santos Carvalho, Alexandra Maria; Muniz de Oliveira, Fábio; Sigurdardóttir, Sunniva; Sunnerhagen, Per; Marques Dourado Bastos, Izabela; Gessner, Richard; Chibale, Kelly; Horta Andrade, Carolina

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子,开发针对恶性疟原虫的多阶段抗疟药物

Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié

Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa

利用人工智能结合药物代谢动力学模型,为非洲疟疾和结核病患者量身定制治疗方案。

Turon, Gemma; Mulubwa, Mwila; Montaner, Anna; Njoroge, Mathew; Chibale, Kelly; Duran-Frigola, Miquel

Psychedelics and Entactogens: Call for Papers

迷幻剂和致幻剂:征稿启事

Aljadeff, Johnatan; Lansdell, Benjamin J; Fairhall, Adrienne L; Kleinfeld, David; Lindsley, Craig W; Hooker, Jacob M; Chibale, Kelly; Müller, Christa E; Booker, Squire J

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Sapanisertib(一种抗癌药物和双重疟原虫磷脂酰肌醇 4-激酶 β 和 cGMP 依赖性蛋白激酶抑制剂,用于治疗疟疾)的药物化学进展

Gachuhi, Samuel; Kamunya, Stephanie; Fienberg, Stephen; Wambua, Lynn; Salomane, Nicolaas; Mayoka, Godfrey; Taylor, Dale; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Birkholtz, Lyn-Marié; Wittlin, Sergio; Krugmann, Liezl; Coulson, Lauren B; Chibale, Kelly