日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

草本萜类化合物通过调节生物能量学激活自噬和线粒体自噬,从而抵御代谢压力、肌肉减少症和表观遗传衰老。

Gabriele Civiletto ,Dario Brunetti ,Giulia Lizzo ,Kamila Muller ,Guillaume E Jacot ,Ioanna Daskalaki ,Federico Sizzano ,Minji Huh ,Ivano Di Meo ,Maria Nicol Colombo ,José L Sanchez-Garcia ,Bertrand J Bétrisey ,Alix Zollinger ,Patricia Lino ,Christopher Neal ,Anne-Laure Egesipe ,Joy Richard ,Myriam Chimen ,Aurélie Hermant ,Benjamin Brinon ,Lorane Texari ,Sylviane Metairon ,Mohammed Adnan Qureshi ,Dhaval S Patel ,Siva A Vanapalli ,Marco Malavolta ,Arwen W Gao ,Amelia Lalou ,Mauro Provinciali ,Fiorenza Orlando ,Valeria Tiranti ,Robert T Brooke ,Steve Horvath ,Johan Auwerx ,Jerome N Feige ,Philipp Gut

ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells

ISB 2001 三特异性 T 细胞接合剂表现出强大的肿瘤细胞毒性并克服多发性骨髓瘤细胞的免疫逃逸机制

Laura Carretero-Iglesia, Olivia J Hall, Jérémy Berret, Daniela Pais, Carole Estoppey, Myriam Chimen, Thierry Monney, Jeremy Loyau, Cyrille Dreyfus, Julie Macoin, Cynthia Perez, Vinu Menon, Isabelle Gruber, Amélie Laurendon, Lydia N Caro, Girish S Gudi, Tomomi Matsuura, Piet H van der Graaf, Stanisla

Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma

开发 ISB 1442,一种用于治疗多发性骨髓瘤的 CD38 和 CD47 双特异性双互补抗体先天细胞调节剂

C Grandclément #, C Estoppey #, E Dheilly #, M Panagopoulou, T Monney, C Dreyfus, J Loyau, V Labanca, A Drake, S De Angelis, A Rubod, J Frei, L N Caro, S Blein, E Martini, M Chimen, T Matthes, Z Kaya, C M Edwards, J R Edwards, E Menoret, C Kervoelen, C Pellat-Deceunynck, P Moreau, M L Mbow, A Srivas

Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss

骨骼修复的治疗途径:利用合成代谢骨肽 PEPITEM 促进骨骼生长并防止骨质流失

Jonathan W Lewis, Kathryn Frost, Georgiana Neag, Mussarat Wahid, Melissa Finlay, Ellie H Northall, Oladimeji Abudu, Samuel Kemble, Edward T Davis, Emily Powell, Charlotte Palmer, Jinsen Lu, G Ed Rainger, Asif J Iqbal, Myriam Chimen, Ansar Mahmood, Simon W Jones, James R Edwards, Amy J Naylor, Helen

Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss

骨修复的治疗途径:利用合成代谢骨肽PEPITEM促进骨骼生长并预防骨质流失

Lewis, Jonathan W; Frost, Kathryn; Neag, Georgiana; Wahid, Mussarat; Finlay, Melissa; Northall, Ellie H; Abudu, Oladimeji; Kemble, Samuel; Davis, Edward T; Powell, Emily; Palmer, Charlotte; Lu, Jinsen; Rainger, G Ed; Iqbal, Asif J; Chimen, Myriam; Mahmood, Ansar; Jones, Simon W; Edwards, James R; Naylor, Amy J; McGettrick, Helen M

Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention

通过 PEPITEM 干预恢复老年小鼠的白细胞运输

Sophie J Hopkin, Poppy Nathan, Laleh Pezhman, Jenefa Begum, Julia E Manning, Lauren M Quinn, G Ed Rainger, Helen M McGettrick #, Asif J Iqbal #, Myriam Chimen #

Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma

ISB 1342(一种用于复发/难治性多发性骨髓瘤的 CD38 × CD3 T 细胞衔接器)的临床前表征

Pouleau, Blandine; Estoppey, Carole; Suere, Perrine; Nallet, Emilie; Laurendon, Amélie; Monney, Thierry; Pais Ferreira, Daniela; Drake, Adam; Carretero-Iglesia, Laura; Macoin, Julie; Berret, Jérémy; Pihlgren, Maria; Doucey, Marie-Agnès; Gudi, Girish S; Menon, Vinu; Udupa, Venkatesha; Maiti, Abhishek; Borthakur, Gautam; Srivastava, Ankita; Blein, Stanislas; Mbow, M Lamine; Matthes, Thomas; Kaya, Zeynep; Edwards, Claire M; Edwards, James R; Menoret, Emmanuelle; Kervoëlen, Charlotte; Pellat-Deceunynck, Catherine; Moreau, Philippe; Zhukovsky, Eugene; Perro, Mario; Chimen, Myriam

Nanoscale clustering of mycobacterial ligands and DC-SIGN host receptors are key determinants for pathogen recognition

分枝杆菌配体和DC-SIGN宿主受体的纳米级聚集是病原体识别的关键决定因素。

Viljoen, Albertus; Vercellone, Alain; Chimen, Myriam; Gaibelet, Gérald; Mazères, Serge; Nigou, Jérôme; Dufrêne, Yves F

PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation

PEPITEM通过调节白细胞迁移来减轻肥胖引起的炎症

Pezhman, Laleh; Hopkin, Sophie J; Begum, Jenefa; Heising, Silke; Nasteska, Daniela; Wahid, Mussarat; Ed Rainger, G; Hodson, David J; Iqbal, Asif J; Chimen, Myriam; McGettrick, Helen M

Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner

衰老以性别特异性的方式调节稳态白细胞向腹腔的运输

Sophie J Hopkin, Laleh Pezhman, Jenefa Begum, Dean Kavanagh, Helen M McGettrick, Asif J Iqbal, Myriam Chimen