Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis.
通过抑制 CDK7 来破坏 RNA 聚合酶 II 转录循环,可以缓解炎症性关节炎
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.adq5091
Chen Xi, Shibu Gayathri, Sokolsky Baila A, Soussana Tamar Nicole, Fisher Logan, Deochand Dinesh K, Dacic Marija, Mantel Ian, Ramirez Daniel C, Bell Richard D, Zhang Tinghu, Donlin Laura T, Goodman Susan M, Gray Nathanael S, Chinenov Yurii, Fisher Robert P, Rogatsky Inez