日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor

使用 HDAC 抑制剂克服实验性癌症恶病质对合成代谢 SARM 疗法的抵抗力

Sophia G Liva, Yu-Chou Tseng, Anees M Dauki, Michael G Sovic, Trang Vu, Sally E Henderson, Yi-Chiu Kuo, Jason A Benedict, Xiaoli Zhang, Bryan C Remaily, Samuel K Kulp, Moray Campbell, Tanios Bekaii-Saab, Mitchell A Phelps, Ching-Shih Chen, Christopher C Coss

Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway

突变的 KRAS 部分通过上调 MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR 信号通路促进结直肠癌肝转移

Po-Chen Chu, Peng-Chan Lin, Hsing-Yu Wu, Kuen-Tyng Lin, Christina Wu, Tanios Bekaii-Saab, Yih-Jyh Lin, Chung-Ta Lee, Jeng-Chang Lee, Ching-Shih Chen

Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo

抑制Jak / STAT信号传导可降低体外胰腺星状细胞的活化并限制体内青霉素诱发的慢性胰腺炎

Hannah M Komar, Gregory Serpa, Claire Kerscher, Erin Schwoegl, Thomas A Mace, Ming Jin, Ming-Chen Yang, Ching-Shih Chen, Mark Bloomston, Michael C Ostrowski, Phil A Hart, Darwin L Conwell, Gregory B Lesinski

Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer

整合素连接激酶作为乳腺癌中 IL-6-NF-κB 信号环路的新型分子开关

En-Chi Hsu, Samuel K Kulp, Han-Li Huang, Huang-Ju Tu, Min-Wu Chao, Yu-Chou Tseng, Ming-Chen Yang, Santosh B Salunke, Nicholas J Sullivan, Wen-Chung Chen, Jianying Zhang, Che-Ming Teng, Wen-Mei Fu, Duxin Sun, Max S Wicha, Charles L Shapiro, Ching-Shih Chen

Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target

整合素连接激酶影响甲状腺癌细胞的信号通路和迁移,是潜在的治疗靶点

Lawrence A Shirley, Samantha McCarty, Ming-Chen Yang, Motoyasu Saji, Xiaoli Zhang, John Phay, Matthew D Ringel, Ching-Shih Chen

Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator

使用新型腺苷酸活化蛋白激酶 (AMPK) 激活剂靶向髓系抑制细胞

Prashant Trikha, Robert L Plews, Andrew Stiff, Shalini Gautam, Vincent Hsu, David Abood, Robert Wesolowski, Ian Landi, Xiaokui Mo, John Phay, Ching-Shih Chen, John Byrd, Michael Caligiuri, Susheela Tridandapani, William Carson

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

多激酶抑制剂可通过其 NH2 末端与热休克蛋白结合,从而抑制分子伴侣功能

Laurence Booth, Brian Shuch, Thomas Albers, Jane L Roberts, Mehrad Tavallai, Stefan Proniuk, Alexander Zukiwski, Dasheng Wang, Ching-Shih Chen, Don Bottaro, Heath Ecroyd, Iryna O Lebedyeva, Paul Dent

Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability

HDAC8通过维持Notch1蛋白稳定性调控乳腺癌干细胞的非表观遗传功能

Min-Wu Chao, Po-Chen Chu, Hsiao-Ching Chuang, Fang-Hsiu Shen, Chih-Chien Chou, En-Chi Hsu, Lauren E Himmel, Han-Li Huang, Huang-Ju Tu, Samuel K Kulp, Che-Ming Teng, Ching-Shih Chen

Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors

利用 γ-生育酚促进 Akt 和 PHLPP1 膜共定位的能力来开发 PHLPP1 靶向 Akt 抑制剂

Ribai Yan, Hsiao-Ching Chuang, Naval Kapuriya, Chih-Chien Chou, Po-Ting Lai, Hsin-Wen Chang, Chia-Ning Yang, Samuel K Kulp, Ching-Shih Chen

A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth

新型双重 AMPK 激活剂/mTOR 抑制剂可抑制甲状腺癌细胞生长

Robert L Plews, Adlina Mohd Yusof, Chaojie Wang, Motoyasu Saji, Xiaoli Zhang, Ching-Shih Chen, Matthew D Ringel, John E Phay