Targeting lncRNA MALAT1 attenuates lenalidomide resistance via CD38 epigenetic modulation, oxidative stress-mediated cell death, and remodeling of the pro-tumor microenvironment in multiple myeloma
靶向lncRNA MALAT1可通过CD38表观遗传调控、氧化应激介导的细胞死亡以及重塑多发性骨髓瘤的促肿瘤微环境来减弱来那度胺耐药性。
期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-025-07252-1
Chang, Wen-Hsin; Liao, Wei-Ting; Yeh, Tsung-Jang; Moi, Sin-Hua; Liu, Yi-Chang; Hsiao, Hui-Hua; Wang, Hui-Ching; Du, Jeng-Shiun; Gau, Yuh-Ching; Yang, Ching-I; Lee, Ching-Ping; Hsu, Chin-Mu; Cho, Shih-Feng
肿瘤
表观遗传
肿瘤免疫
多发性骨髓瘤
氧化应激
信号转导
LAT
LAT1
CD3
CD38
骨髓瘤
lncRNA
细胞生物学
毒理研究
肿瘤微环境