Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
通过基于吡咯的二氢乳清酸脱氢酶抑制剂系列的结构导向计算优化,鉴定出具有开发潜力的强效抗疟药物
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c00173
Palmer, Michael J; Deng, Xiaoyi; Watts, Shawn; Krilov, Goran; Gerasyuto, Aleksey; Kokkonda, Sreekanth; El Mazouni, Farah; White, John; White, Karen L; Striepen, Josefine; Bath, Jade; Schindler, Kyra A; Yeo, Tomas; Shackleford, David M; Mok, Sachel; Deni, Ioanna; Lawong, Aloysus; Huang, Ann; Chen, Gong; Wang, Wen; Jayaseelan, Jaya; Katneni, Kasiram; Patil, Rahul; Saunders, Jessica; Shahi, Shatrughan P; Chittimalla, Rajesh; Angulo-Barturen, Iñigo; Jiménez-Díaz, María Belén; Wittlin, Sergio; Tumwebaze, Patrick K; Rosenthal, Philip J; Cooper, Roland A; Aguiar, Anna Caroline Campos; Guido, Rafael V C; Pereira, Dhelio B; Mittal, Nimisha; Winzeler, Elizabeth A; Tomchick, Diana R; Laleu, Benoît; Burrows, Jeremy N; Rathod, Pradipsinh K; Fidock, David A; Charman, Susan A; Phillips, Margaret A