日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

APOE3基因中的R136S突变通过抑制cGAS-STING-IFN通路赋予机体抵抗tau蛋白病理的能力。

Sarah Naguib,Chloe Lopez-Lee,Eileen Ruth Torres,Se-In Lee,Jingjie Zhu,Daphne Zhu,Pearly Ye,Kendra Norman,Mingrui Zhao,Man Ying Wong,Yohannes A Ambaw,Rodrigo Muñoz-Castañeda,Wei Wang,Tark Patel,Maitreyee Bhagwat,Rada Norinsky,Sue-Ann Mok,Tobias C Walther,Robert V Farese Jr,Wenjie Luo,Subhash C Sinha,Zhuhao Wu,Li Fan,Shiaoching Gong,Li Gan

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice

DAP12 缺失可减少雌性 tau 蛋白病小鼠的神经元 SLIT2 表达和脱髓鞘,并增强其大脑的恢复能力。

Hao Chen ,Li Fan ,Qi Guo ,Man Ying Wong ,Jingjie Zhu ,Nessa Foxe ,Winston Wang ,Aviram Nessim ,Gillian Carling ,Bangyan Liu ,Chloe Lopez-Lee ,Yige Huang ,Sadaf Amin ,Tark Patel ,Sue-Ann Mok ,Won-Min Song ,Bin Zhang ,Shiaoching Gong ,Qin Ma ,Hongjun Fu ,Li Gan ,Wenjie Luo

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

APOE3-R136S 突变通过 cGAS-STING-IFN 抑制赋予对 tau 病理的抵抗力

Sarah Naguib, Eileen Ruth Torres, Chloe Lopez-Lee, Li Fan, Maitreyee Bhagwat, Kendra Norman, Se-In Lee, Jingjie Zhu, Pearly Ye, Man Ying Wong, Tark Patel, Sue-Ann Mok, Wenjie Luo, Subhash Sinha, Mingrui Zhao, Shiaoching Gong, Li Gan

Both Nuclear and Membrane Estrogen Receptor Alpha Impact the Expression of Estrogen Receptors and Plasticity Markers in the Mouse Hypothalamus and Hippocampus

核和膜雌激素受体 α 均影响小鼠下丘脑和海马中雌激素受体和可塑性标志物的表达

Sanoara Mazid, Elizabeth M Waters, Chloe Lopez-Lee, Renata Poultan Kamakura, Batsheva R Rubin, Ellis R Levin, Bruce S McEwen, Teresa A Milner

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

DAP12 缺乏会改变小胶质细胞-少突胶质细胞间的通讯并增强对 tau 毒性的抵抗力

Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Fangmin Yu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Sue-Ann Mok, Won-Min Song, Bin Zhang, Qin Ma, Hongjun Fu, Li Gan, Wenjie Luo