Cho Sungwoo相关文献与解析，生知库 | 链接生命科学的每一步

Cho, Sungwoo; Nguyen, Quoc Huynh; de Hoyos-Vega, Jose Manolo; Bharath, Ananya; Gonzalez-Suarez, Alan M; Nguyen, Kianna M; Che, Quang Tuan; Gwon, Kihak; Matveyenko, Aleksey; Stybayeva, Gulnaz; Revzin, Alexander

细胞生物学

发表日期：2026

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Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential

克服“不可成药”障碍：基于结构的CD28小分子拮抗剂的发现及其转化潜力

期刊:Biomedicine & Pharmacotherapy

影响因子:7.5

doi:10.1016/j.biopha.2025.118937

Upadhyay, Saurabh; Nada, Hossam; Cho, Sungwoo; Gabr, Moustafa T

TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization

首创直接小分子激动剂激活TREM2：DEL筛选、优化、生物物理验证和功能表征

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2025.118358

Nada, Hossam; Yuan, Shaoren; El Gaamouch, Farida; Cho, Sungwoo; Kuncewicz, Katarzyna; Calvo-Barreiro, Laura; Gabr, Moustafa T

TREM2

发表日期：2026

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AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Functional Microglial Activity

人工智能辅助发现和优化具有功能性小胶质细胞活性的小分子TREM2激动剂

期刊:ACS Medicinal Chemistry Letters

影响因子:4

doi:10.1021/acsmedchemlett.5c00542

Cho, Sungwoo; Szalai, Tibor Viktor; El Gaamouch, Farida; Bajusz, Dávid; Keserű, György M; Gabr, Moustafa

Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces

利用核磁共振谱系异质性实现针对动态蛋白质-蛋白质界面的小分子发现

期刊:

影响因子:

doi:10.64898/2026.02.04.703700

Nada, Hossam; Cho, Sungwoo; Abdo, Ashraf N; Gabr, Moustafa

发表日期：2026

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Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer's Models

TREM2小分子激动剂可重编程小胶质细胞并保护人类阿尔茨海默病模型中的突触

期刊:

影响因子:

doi:10.64898/2026.01.19.700278

Nada, Hossam; Yuan, Shaoren; Gaamouch, Farida El; Cho, Sungwoo; Gabr, Moustafa T

Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927

临床阶段 TREM2 激动剂 VG-3927 与 Aβ 重叠的胞外结构域结合

期刊:

影响因子:

doi:10.64898/2026.03.02.709194

Cho, Sungwoo; Gabr, Moustafa T

TREM2

发表日期：2026

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Development of a NanoBiT based high throughput screening assay for discovery of NOS1-CAPON interaction inhibitors

开发基于NanoBiT的高通量筛选方法，用于发现NOS1-CAPON相互作用抑制剂

期刊:

影响因子:

doi:10.64898/2026.01.25.701608

Cho, Sungwoo; Gabr, Moustafa T

发表日期：2026

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As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition

As48，一种首创的双功能TREM2调节剂：受体激活和脱落抑制

期刊:Biomedicine & Pharmacotherapy

影响因子:7.5

doi:10.1016/j.biopha.2025.118862

Cho, Sungwoo; El Gaamouch, Farida; Upadhyay, Saurabh; Nada, Hossam; Kuncewicz, Katarzyna; Gabr, Moustafa T

Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models.

基于结构的虚拟筛选鉴定出有效的 CD28 抑制剂，这些抑制剂能够抑制细胞和粘膜模型中的 T 细胞共刺激。

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2025.118194

Upadhyay Saurabh, Talagayev Valerij, Cho Sungwoo, Wolber Gerhard, Gabr Moustafa

Multicompartment hydrogel microcapsules for creating spatially patterned cell co-cultures

用于构建空间图案化细胞共培养的多室水凝胶微胶囊

Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential

克服“不可成药”障碍：基于结构的CD28小分子拮抗剂的发现及其转化潜力

TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization

首创直接小分子激动剂激活TREM2：DEL筛选、优化、生物物理验证和功能表征

AI-Assisted Discovery and Optimization of Small-Molecule TREM2 Agonists with Functional Microglial Activity

人工智能辅助发现和优化具有功能性小胶质细胞活性的小分子TREM2激动剂

Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces

利用核磁共振谱系异质性实现针对动态蛋白质-蛋白质界面的小分子发现

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer's Models

TREM2小分子激动剂可重编程小胶质细胞并保护人类阿尔茨海默病模型中的突触

Aβ-Overlapping Ectodomain Binding of the Clinical-Stage TREM2 Agonist VG-3927

临床阶段 TREM2 激动剂 VG-3927 与 Aβ 重叠的胞外结构域结合

Development of a NanoBiT based high throughput screening assay for discovery of NOS1-CAPON interaction inhibitors

开发基于NanoBiT的高通量筛选方法，用于发现NOS1-CAPON相互作用抑制剂

As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition

As48，一种首创的双功能TREM2调节剂：受体激活和脱落抑制

Structure-based virtual screening identifies potent CD28 inhibitors that suppress T cell co-stimulation in cellular and mucosal models.

基于结构的虚拟筛选鉴定出有效的 CD28 抑制剂，这些抑制剂能够抑制细胞和粘膜模型中的 T 细胞共刺激。