日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preliminary and Ongoing Investigation of Human Induced Pluripotent Stem Cell‐Derived Frontotemporal Dementia Cortical Organoids Assessed by Mass Spectrometry

利用质谱法对人诱导多能干细胞衍生的额颞叶痴呆皮质类器官进行初步和持续研究

Pagano, Nathan; Perez, Gerard Aguilar; Garcia-Milian, Rolando; Manuelidis, Laura; Anwer, Mehwish; Swaro, Aditya; Bristow, Brianna; Fan, Jianjia; Cheng, Wai Hang; Cembrowski, Mark; Wellington, Cheryl L; Lorincz‐Comi, Noah J; Cheng, Feixiong; Song, Wenqiang; Chen, Xin; Paz, Isabela Rivera; Hou, Yuan; Zhou, Yadi; Xu, Jielin; Martin, William; Pieper, Andrew A; Haines, Jonathan L; Mina, Chung; Wendt, Stefan; Lin, Ada J; Ebert, Sarah N; Brennan, Declan J; Cai, Wenji; Bai, Yanyang; Kong, Da Young; Sorrentino, Stefano; Groten, Christopher J; Lee, Christopher; Frew, Jonathan; Choi, Hyun B; Karamboulas, Konstantina; Delhaye, Mathias; Kaplan, David R; Miller, Freda; MacVicar, Brian A; Nygaard, Haakon B; Lorincz‐Comi, Noah J; Cheng, Feixiong; Wijesinghe, Printha; Xi, Jeanne; Campbell, Matthew; Chen, Si Xuan; Pham, Wellington; Matsubara, Joanne A; Xu, Jielin; Zhou, Yadi; Lorincz‐Comi, Noah J; Dou, Lijun; Hou, Yuan; Qiu, Yunguang; Pieper, Andrew A; Cheng, Feixiong; Best, Merci N; Lamp, Jared; Umstead, Andrew; Sierra, Mariana; Spencer, Amber; Erturk, Ilkim; Tank, Elizabeth M; Sexton, Jonathan; Barmada, Sami; Vega, Irving E; Paulson, Henry L

Simultaneous imaging of redox states in dystrophic neurites and microglia at Aβ plaques indicate lysosome accumulation not microglia correlate with increased oxidative stress

对Aβ斑块处营养不良性神经突和微胶质细胞的氧化还原状态进行同步成像表明,溶酶体积累而非微胶质细胞积累与氧化应激增加相关。

Wendt, Stefan; Johnson, Sora; Weilinger, Nicholas L; Groten, Christopher; Sorrentino, Stefano; Frew, Jonathan; Yang, Lucy; Choi, Hyun B; Nygaard, Haakon B; MacVicar, Brian A

Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's disease

在阿尔茨海默病动物模型中,白细胞介素-8受体CXCR2的药理学拮抗作用可抑制炎症反应并发挥神经保护作用。

Ryu, Jae K; Cho, T; Choi, Hyun B; Jantaratnotai, N; McLarnon, James G

Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth

神经元NMDA受体的激活会触发短暂的ATP介导的小胶质细胞突起生长

Dissing-Olesen, Lasse; LeDue, Jeffrey M; Rungta, Ravi L; Hefendehl, Jasmin K; Choi, Hyun B; MacVicar, Brian A

Increased 20-HETE synthesis explains reduced cerebral blood flow but not impaired neurovascular coupling after cortical spreading depression in rat cerebral cortex

大鼠大脑皮层扩散性抑制后,20-HETE合成增加可解释脑血流量减少,但不能解释神经血管耦合受损。

Fordsmann, Jonas C; Ko, Rebecca W Y; Choi, Hyun B; Thomsen, Kirsten; Witgen, Brent M; Mathiesen, Claus; Lønstrup, Micael; Piilgaard, Henning; MacVicar, Brian A; Lauritzen, Martin

Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides.

利用 TLR4 受体干扰肽预防 LPS 诱导的小胶质细胞活化、细胞因子产生和疾病行为

Hines Dustin J, Choi Hyun B, Hines Rochelle M, Phillips Anthony G, MacVicar Brian A

Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase

星形胶质细胞和神经元之间通过碳酸氢盐反应性可溶性腺苷酸环化酶进行代谢通讯

Choi, Hyun B; Gordon, Grant R J; Zhou, Ning; Tai, Chao; Rungta, Ravi L; Martinez, Jennifer; Milner, Teresa A; Ryu, Jae K; McLarnon, James G; Tresguerres, Martin; Levin, Lonny R; Buck, Jochen; MacVicar, Brian A

Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology.

小胶质细胞 VEGF 受体反应是阿尔茨海默病病理学中一个不可或缺的趋化成分

Ryu Jae K, Cho Taesup, Choi Hyun B, Wang Yu Tian, McLarnon James G

Brain metabolism dictates the polarity of astrocyte control over arterioles.

脑代谢决定了星形胶质细胞对小动脉的控制极性

Gordon Grant R J, Choi Hyun B, Rungta Ravi L, Ellis-Davies Graham C R, MacVicar Brian A

Platelet-activating factor enhancement of calcium influx and interleukin-6 expression, but not production, in human microglia

血小板激活因子增强人小胶质细胞中钙离子内流和白细胞介素-6的表达,但不影响其生成。

Sattayaprasert, Prasongchai; Choi, Hyun B; Chongthammakun, Sukumal; McLarnon, James G