The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity
Wnt受体Ryk通过抑制突变亨廷顿蛋白致病早期阶段的FOXO活性来降低神经元和细胞的存活能力。
期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.1001895
Tourette, Cendrine; Farina, Francesca; Vazquez-Manrique, Rafael P; Orfila, Anne-Marie; Voisin, Jessica; Hernandez, Sonia; Offner, Nicolas; Parker, J Alex; Menet, Sophie; Kim, Jinho; Lyu, Jungmok; Choi, Si Ho; Cormier, Kerry; Edgerly, Christina K; Bordiuk, Olivia L; Smith, Karen; Louise, Anne; Halford, Michael; Stacker, Steven; Vert, Jean-Philippe; Ferrante, Robert J; Lu, Wange; Neri, Christian
信号转导
细胞生物学
Wnt/β-Catenin
神经科学
