文献库，生知库 | 链接生命科学的每一步

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

NADPH氧化酶抑制剂通过减轻阿尔茨海默病中的tau蛋白病变和神经炎症来促进大脑恢复力

doi:10.1002/advs.202505495

Lee, Jihyeon; Sim, Seunghwan; Jin, Yinglan; Park, Hyejun; Byeon, Eun Young; Kim, Su Jin; Yun, Sujin; Lee, Hye Eun; Jeong, Da Un; Suh, Jung Min; Lee, In Hye; Lee, Ho-Young; Choi, Yongseok; Bae, Yun Soo

LMT2368 (1-(4-Chlorophenyl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)urea) Negatively Regulates Inflammation by Inhibiting NLRP3 Inflammasome Activation.

LMT2368（1-(4-氯苯基)-3-(3-氟-5-(三氟甲基)苯基)脲）通过抑制NLRP3炎症小体激活来负向调节炎症。

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics17101241

Nguyen Thai Uy, Kwon Su Jeong, Hurh Sunghoon, Kale Ashok, Cho Jae Min, Nada Hossam, Kim Chang Seong, Induvadana Peela, Park Beom Jin, Lee Kyeong, Choi Yongseok, Hwang Jong-Ik

炎症/感染

LRP3

NLRP3

Immunology/Inflammation

炎性小体

发表日期：2025

文献求助收藏

The fluoroquinolone compounds potentiate the antifungal activity of the echinocandins against Aspergillus fumigatus

氟喹诺酮类化合物可增强棘白菌素类药物对烟曲霉的抗真菌活性。

期刊:Bioscience Reports

影响因子:4.7

doi:10.1042/BSR20250001

Choi, Jin-Ju; Kang, Suzie; Lee, Yoonseo; Lee, Dong-Hyun; Jang, Yuju; Goo, Ja-Il; Choi, Yongseok; Lee, Dongho; Yun, Cheol-Won

微生物学

发表日期：2025

文献求助收藏

Preliminary evaluation of the effect of revised reimbursement scheme in outpatient hemodialysis for medical aid recipients in Korea

韩国医疗援助受益人门诊血液透析报销方案修订效果的初步评估

期刊:Kidney Research and Clinical Practice

影响因子:3.8

doi:10.23876/j.krcp.23.038

Kim, Heenyun; Choi, Yongseok; Kwon, Soontack; Jang, Kook Young; Ryuk, Do Kyung; Lee, Hyejin; Lee, Jin Yong

发表日期：2025

文献求助收藏

Branched Hyaluronic Acid for Reduced Viscosity and Enhanced Moisturization

支链透明质酸可降低粘度并增强保湿效果

期刊:Materials

影响因子:3.2

doi:10.3390/ma18214882

Lee, Hyun Ji; Lee, In Young; Choi, Yongseok; Lee, Yun-Chan; Lee, Kuen Yong

发表日期：2025

文献求助收藏

New insights into protein-protein interaction modulators in drug discovery and therapeutic advance

蛋白质-蛋白质相互作用调节剂在药物发现和治疗进展中的新见解

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-024-02036-3

Nada, Hossam; Choi, Yongseok; Kim, Sungdo; Jeong, Kwon Su; Meanwell, Nicholas A; Lee, Kyeong

发表日期：2024

文献求助收藏

3-Hydroxytanshinone Inhibits the Activity of Hypoxia-Inducible Factor 1-α by Interfering with the Function of α-Enolase in the Glycolytic Pathway

3-羟基丹参酮通过干扰糖酵解途径中α-烯醇化酶的功能来抑制缺氧诱导因子1-α的活性。

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules29102218

Son, Tae Hyun; Kim, Shin-Hye; Shin, Hye-Lim; Kim, Dongsoo; Kim, Hwan Gyu; Choi, Yongseok; Choi, Sik-Won

发表日期：2024

文献求助收藏

Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR)

小分子c-KIT抑制剂在胃肠道间质瘤治疗中的应用：合成、设计策略及构效关系（SAR）综述

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms24119450

Godesi, Sreenivasulu; Lee, Joohan; Nada, Hossam; Quan, Guofeng; Elkamhawy, Ahmed; Choi, Yongseok; Lee, Kyeong

KIT

发表日期：2023

文献求助收藏

Cantharidin-Based Verbenone Derivatives as a Novel Insecticide against Plutella xylostella: Design, Synthesis, Insecticidal Activity Evaluation, and 3D QSAR Study

基于斑蝥素的马鞭草酮衍生物作为新型小菜蛾杀虫剂：设计、合成、杀虫活性评价及三维定量构效关系研究

期刊:Biomolecules

影响因子:4.8

doi:10.3390/biom13081272

Lee, Kwanshik; Nada, Hossam; Kim, Minkyoung; Park, Hyejun; Lee, Kiho; Seo, Dongho; Lee, Kyeong; Choi, Yongseok

发表日期：2023

文献求助收藏

Measuring Trends in Disability-adjusted Life Years and Life Expectancy in Korea: 2008 to 2021

韩国残疾调整生命年和预期寿命趋势测量：2008年至2021年

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

NADPH氧化酶抑制剂通过减轻阿尔茨海默病中的tau蛋白病变和神经炎症来促进大脑恢复力

LMT2368 (1-(4-Chlorophenyl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)urea) Negatively Regulates Inflammation by Inhibiting NLRP3 Inflammasome Activation.

LMT2368（1-(4-氯苯基)-3-(3-氟-5-(三氟甲基)苯基)脲）通过抑制NLRP3炎症小体激活来负向调节炎症。

The fluoroquinolone compounds potentiate the antifungal activity of the echinocandins against Aspergillus fumigatus

氟喹诺酮类化合物可增强棘白菌素类药物对烟曲霉的抗真菌活性。

Preliminary evaluation of the effect of revised reimbursement scheme in outpatient hemodialysis for medical aid recipients in Korea

韩国医疗援助受益人门诊血液透析报销方案修订效果的初步评估

Branched Hyaluronic Acid for Reduced Viscosity and Enhanced Moisturization

支链透明质酸可降低粘度并增强保湿效果

New insights into protein-protein interaction modulators in drug discovery and therapeutic advance

蛋白质-蛋白质相互作用调节剂在药物发现和治疗进展中的新见解

3-Hydroxytanshinone Inhibits the Activity of Hypoxia-Inducible Factor 1-α by Interfering with the Function of α-Enolase in the Glycolytic Pathway

3-羟基丹参酮通过干扰糖酵解途径中α-烯醇化酶的功能来抑制缺氧诱导因子1-α的活性。

Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR)

小分子c-KIT抑制剂在胃肠道间质瘤治疗中的应用：合成、设计策略及构效关系（SAR）综述

Cantharidin-Based Verbenone Derivatives as a Novel Insecticide against Plutella xylostella: Design, Synthesis, Insecticidal Activity Evaluation, and 3D QSAR Study

基于斑蝥素的马鞭草酮衍生物作为新型小菜蛾杀虫剂：设计、合成、杀虫活性评价及三维定量构效关系研究