Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-X(L) degradation to overcome cancer chemoresistance.
紫杉醇诱导的有丝分裂停滞导致细胞凋亡依赖性的趋同，而这种趋同可以通过 BCL-X(L) 降解来安全地利用，从而克服癌症的化疗耐药性
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doi:10.1101/2025.06.24.661170
Qin Xingping, Presser Adam, Johnson Lissah, Matoba Yusuke, Shay Brendan S, Xu Weiyi, Choiniere Jonathan, Fraser Cameron, Garbicz Filip, Spetz Johan, Yu Stacey, Florido Mary H C, Picucci Francesca, Yang Yang, Drapkin Ronny, Carrasco Ruben, Hill Sarah J, Liu Joyce, Matulonis Ursula, Brugge Joan, Rueda Bo R, Zhou Daohong, Stover Elizabeth H, Sarosiek Kristopher A
